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Submit ReviewAnagrelide hydrochloride
Description: Potent PDE3 inhibitor
Alternative Names: BL 4162A
Chemical Name: 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Anagrelide hydrochloride
Anagrelide hydrochloride is a potent type III phosphodiesterase (PDE3) inhibitor (IC50 = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.
Technical Data for Anagrelide hydrochloride
| M. Wt | 292.55 |
| Formula | C10H7Cl2N3O.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 58579-51-4 |
| PubChem ID | 42786 |
| InChI Key | TVWRQCIPWUCNMI-UHFFFAOYSA-N |
| Smiles | ClC1=C(CN(C3)C(N2)=NC3=O)C2=CC=C1Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Anagrelide hydrochloride
References for Anagrelide hydrochloride
References are publications that support the biological activity of the product.
Gillespie (1988) Anagrelide: a potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity. Biochem.Pharmacol. 37 2866 PMID: 2456068
Mazur et al (1992) Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans. Blood 79 1931 PMID: 1562721
Wang et al (2005) Comparison of the biological activities of anagr. and its major metabolites in haematopoietic cell cultures. Br.J.Pharmacol. 146 324 PMID: 16041400
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Keywords: Anagrelide hydrochloride, Anagrelide hydrochloride supplier, Potent, PDE3, inhibitors, inhibits, Phosphodiesterases, BL4162A, BL, 4162A, 2432, Tocris Bioscience
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