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Submit ReviewANQ 11125 is a selective motilin receptor antagonist (pKd = 8.24). Exhibits no effect on acetylcholine, substance P or serotonin stimulated intestinal contraction.
M. Wt | 1761.05 |
Formula | C86H125N19O21 |
Sequence | FVFIFTYGELQRLQ |
Storage | Store at -20°C |
CAS Number | 153966-48-4 |
PubChem ID | 90489005 |
InChI Key | YQKDYBMNXFOSLF-SDGXXZENSA-N |
Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Depoortere et al (1995) Antagonistic properties of [Phe3,Leu13]porcine motilin. Eur.J.Pharmacol. 286 241 PMID: 8608785
Peeters et al (1994) The motilin antagonist ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit. Biochem.Biophys.Res.Commun. 198 411 PMID: 8297350
Keywords: ANQ 11125, ANQ 11125 supplier, ANQ11125, Motilin, receptor, antagonists, motilides, Receptors, 5074, Tocris Bioscience
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