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Antagonist G

Cat. No. 1954 Submit a Review Datasheet / COA / SDS

Discontinued Product

1954 has been discontinued.

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Description: Broad spectrum neuropeptide receptor antagonist
Alternative Names: [Arg6,D-Trp7,9,N-MePhe8]-Substance P(6-11)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Datasheets References

Biological Activity for Antagonist G

Antagonist G is a substance P analog that is a broad spectrum neuropeptide antagonist and antiproliferative agent. Blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. Inhibits neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro; activates JNK and stimulates apoptosis. Inhibits growth of SCLC xenografts in mice in vivo.

Technical Data for Antagonist G

M. Wt 951.2
Formula C49H66N12O6S
Sequence RWFWLM

(Modifications: Trp-2 = D-Trp, Phe-3 = N-Methyl-Phe, Trp-5 = D-Trp, Met-7 = C-terminal amide)
Storage Desiccate at -20°C
CAS Number 115150-59-9
PubChem ID 163960
InChI Key CUCSSYAUKKIDJV-FAXBSAIASA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Antagonist G

References are publications that support the biological activity of the product.

Woll and Rozengurt (1990) A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res. 50 3968 PMID: 1693879

Langdon et al (1992) Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo. Cancer Res. 52 4554 PMID: 1379515

MacKinnon et al (2000) [Arg6, D-Trp7,9, NmePhe8]-Substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy. Br.J.Cancer 83 941 PMID: 10970698

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Keywords: Antagonist G, Antagonist G supplier, Broad, spectrum, neuropeptide, receptors, antagonists, Tachykinin, Non-Selective, Neurokinin, AntagonistG, neuropeptides, [Arg6,D-Trp7,9,N-MePhe8]-Substance, P(6-11), Other, Peptide, Receptors, 1954, Tocris Bioscience

Citations for Antagonist G

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.