Home / Pharmacology / Transporters / Ion Pumps/Transporters / Monocarboxylate Transporters / Monocarboxylate Transporter Inhibitors / AR-C 141990 hydrochloride

AR-C 141990 hydrochloride

Cat. No. 5658 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: MCT1 inhibitor
Chemical Name: 5-[[(3R)-3-Hydroxy-1-pyrrolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-6-(4-quinolinylmethyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AR-C 141990 hydrochloride

AR-C 141990 hydrochloride is a monocarboxylate transporter (MCT1) inhibitor (pKi = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs cardiac graft survival in a rat model. Immunosuppressant. Also inhibits brain penetration of GHB analog HOCPCA.

Technical Data for AR-C 141990 hydrochloride

M. Wt 529.05
Formula C26H28N4O4S.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2250019-94-2
PubChem ID 129316183
InChI Key NFFGLQDNUHBVEY-UNTBIKODSA-N
Smiles O=C(N1C[C@H](O)CC1)C2=C(CC3=C4C(C=CC=C4)=NC=C3)SC(N5CC(C)C)=C2C(N(C)C5=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AR-C 141990 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 49.26 100
DMSO 49.26 100

Preparing Stock Solutions for AR-C 141990 hydrochloride

The following data is based on the product molecular weight 529.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.89 mL 9.45 mL 18.9 mL
5 mM 0.38 mL 1.89 mL 3.78 mL
10 mM 0.19 mL 0.95 mL 1.89 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for AR-C 141990 hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for AR-C 141990 hydrochloride

References are publications that support the biological activity of the product.

Påhlman et al (2012) Immunosuppressive properties of a series of novel inhibitors of the monocarboxylate transporter MCT-1. Transpl.Int. 26 22 PMID: 23137339

Thiesen et al (2015) In vitro and in vivo evidence for active brain uptake of the GHB analog HOCPCA by the monocarboxylate transporter subtype 1. J.Pharmacol.Exp.Ther. 354 166 PMID: 25986445

If you know of a relevant reference for AR-C 141990 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Monocarboxylate Transporter Inhibitors

Keywords: AR-C 141990 hydrochloride, AR-C 141990 hydrochloride supplier, AR-C141990, HCl, monocarboxylate, transporter, 1, MCT1, immunosuppressant, graft, versus, host, GvH, transplant, Monocarboxylate, Transporters, 5658, Tocris Bioscience

Citations for AR-C 141990 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for AR-C 141990 hydrochloride. Do you know of a great paper that uses AR-C 141990 hydrochloride from Tocris? Please let us know.

Reviews for AR-C 141990 hydrochloride

There are currently no reviews for this product. Be the first to review AR-C 141990 hydrochloride and earn rewards!

Have you used AR-C 141990 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.