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Submit ReviewArcyriaflavin A
Discontinued Product
2457 has been discontinued.
View all CDK4 Subfamily (CDK4 & CDK6) products.
Description: Potent cdk4 inhibitor; also potently inhibits CaM kinase II; antiviral
Chemical Name: 12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
Purity: ≥98% (HPLC)
Biological Activity for Arcyriaflavin A
Arcyriaflavin A is a potent cyclin-dependent kinase 4 (cdk4) inhibitor (IC50 value reported between 60 and 190 nM). Displays activity at other cdks in the sub-micromolar range. Also potently inhibits CaM kinase II (IC50 = 25 nM). Inhibits human cytomegalovirus (HCMV) replication in vitro.
Compound Libraries for Arcyriaflavin A
Arcyriaflavin A is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for Arcyriaflavin A
| M. Wt | 325.32 |
| Formula | C20H11N3O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 118458-54-1 |
| PubChem ID | 5327723 |
| InChI Key | KAJXOWFGKYKMMZ-UHFFFAOYSA-N |
| Smiles | O=C1NC(=O)C2=C1C1=C(NC3=CC=CC=C13)C1=C2C2=C(N1)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Arcyriaflavin A
References for Arcyriaflavin A
References are publications that support the biological activity of the product.
Slater et al (1999) Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg.Med.Chem. 7 1067 PMID: 10428375
Zhu et al (2003) Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors. Bioorg.Med.Chem.Lett. 13 1231 PMID: 12657252
Sanchez-Martinez et al (2003) Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors. Bioorg.Med.Chem.Lett. 13 3835 PMID: 14552791
Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987
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Keywords: Arcyriaflavin A, Arcyriaflavin A supplier, Potent, CaM, Kinase, II, cdk4, cyclin, D1, inhibitors, inhibits, Antiviral, agent, anti-HCMV, Calmodulin-Activated, calmodulin-dependent, Protein, Kinases, Cdk, Cyclin-Dependent, Ca2+, Binding, modulators, Calmodulin, Calcium, Signaling, Signalling, ArcyriaflavinA, Cyclin-dependent, Cytomegalovirus, CDK4, Subfamily, 2457, Tocris Bioscience
Citations for Arcyriaflavin A
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Currently there are no citations for Arcyriaflavin A.
Reviews for Arcyriaflavin A
Average Rating: 5 (Based on 1 Review.)
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Arcyriaflavin A was observed for its activity on cell viability, proliferation, and angiogenesis of ECSCs.
By
Anonymous on 12/24/2019
Species: Human
Arcyriaflavin A was observed for its activity on cell viability, proliferation, and angiogenesis of ECSCs as assessed using the 5-bromo-2-deoxyuridine (BrdU) and methylthiazoletetrazolium bromide (MTT) assays, and vascular endothelial growth factor (VEGF) ELISA.
