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Description: Potent N-acylethanolamine acid amidase inhibitor; NAAA activity-based protein profiling (ABPP) probe
Chemical Name: (S)-Undec-10-yn-1-yl (2-oxoazetidin-3-yl)carbamate
Purity: ≥98% (HPLC)
Biological Activity for ARN 14686
ARN 14686 is a NAAA (N-acylethanolamine acid amidase) activity-based protein profiling (ABPP) probe. Can be used to detect NAAA in cell lysates or intact cells. Covalently binds the N-terminal cysteine of catalytically active NAAA. Detects catalytically active NAAA in inflamed rat paw in CFA model of inflammation. Potent NAAA inhibitor (IC50 = 6 nM).
Technical Data for ARN 14686
| M. Wt | 280.36 |
| Formula | C15H24N2O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1628345-10-7 |
| PubChem ID | 118915444 |
| InChI Key | XEXRAYPXQNELAS-ZDUSSCGKSA-N |
| Smiles | O=C(OCCCCCCCCCC#C)N[C@H]1CNC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ARN 14686
References for ARN 14686
References are publications that support the biological activity of the product.
Romeo et al (2015) Activity-based probe for N-acylethanolamine acid amidase. ACS Chem.Biol. 10 2057 PMID: 26102511
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Keywords: ARN 14686, ARN 14686 supplier, ARN14686, NAAA, N-acylethanolamine, acid, amidase, activity-based, protein, profiling, ABPP, probes, inhibits, inhibitors, Other, Hydrolases, Biochemicals, and, Molecular, Biology, 5862, Tocris Bioscience
Citations for ARN 14686
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