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Submit ReviewAS 2031477
Description: Selective FFA1 (GPR40) agonist
Chemical Name: 2-Fluoro-4-[[[1,2,3,4-Tetrahydro-1-(2-phenoxyethyl)-5-quinolinyl]methyl]amino]benzenepropanoic acid
Purity: ≥98% (HPLC)
Biological Activity for AS 2031477
AS 2034178 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist. Exhibits selectivity for GPR40 over GPR41, GPR43, GPR119, GPR120 and PPARγ. Induces glucose-dependent insulin secretion in pancreatic MIN6 cells and in vivo. Enhances insulin sensitivity in a type 2 diabetes model in vivo. Orally available.
Technical Data for AS 2031477
| M. Wt | 448.53 |
| Formula | C27H29FN2O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1030846-42-4 |
| PubChem ID | 24808572 |
| InChI Key | VENOXIKBBUVHRY-UHFFFAOYSA-N |
| Smiles | FC1=C(CCC(O)=O)C=CC(NCC2=C(CCCN3CCOC4=CC=CC=C4)C3=CC=C2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AS 2031477
References for AS 2031477
References are publications that support the biological activity of the product.
Tanaka et al (2013) Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent Ins secretion. J.Pharmacol.Exp.Ther. 346 443 PMID: 23853170
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Keywords: AS 2031477, AS 2031477 supplier, AS, 2031477, selective, free, fatty, acid, receptors, FFA1, GPR40, agonists, diabetes, insulin, sensitivity, FFAR1, Free, Fatty, Acid, Receptors, 5035, Tocris Bioscience
Citations for AS 2031477
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