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Submit ReviewATC 0065
Discontinued Product
3359 has been discontinued.
View all Melanin-concentrating Hormone Receptors products.
Description: Potent and selective MCH1 antagonist
Chemical Name: N2-[cis-4-[[2-[4-Bromo-2-(trifluoromethoxy)phenyl]ethyl]amino]cyclohexyl]-N4,N4-dimethyl-2,4-quinazolinediamine dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for ATC 0065
Orally active, potent and selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 15.7 nM) that displays > 96-fold selectivity over MCH2. Exhibits antidepressant and anxiolytic activity in vivo. Also displays affinity for 5-HT1A and 5-HT2B receptors (IC50 values are 62.9 and 266 nM respectively).
Technical Data for ATC 0065
| M. Wt | 625.35 |
| Formula | C25H29BrF3N5O.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 510732-84-0 |
| PubChem ID | 11479128 |
| InChI Key | BPGUWYBAINNZQH-UHFFFAOYSA-N |
| Smiles | BrC(C=C4)=CC(OC(F)(F)F)=C4CCN[C@@H](CC3)CC[C@@H]3NC2=NC1=CC=CC=C1C(N(C)C)=N2.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ATC 0065
References for ATC 0065
References are publications that support the biological activity of the product.
Kanuma et al (2006) Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists. Bioorg.Med.Chem. 14 3307 PMID: 16434202
Chaki et al (2005) Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: Nonpeptide and orally active melanin-concentrating hormone receptor 1 antagonists. J.Pharmacol.Exp.Ther. 313 832
Dyck et al (2005) Small molecule melanin-concentrating hormone receptor 1 (MCH1R) antagonists as anxiolytic and antidepressive agents. Drug Dev.Res. 65 291
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Citations for ATC 0065
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.