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Submit ReviewAtosiban
Description: Potent oxytocin receptor antagonist
Purity: ≥98% (HPLC)
Biological Activity for Atosiban
Atosiban is a potent oxytocin receptor (OTR) antagonist. Inhibits oxytocin-induced increase in Ca2+ concentration in myometrial cells in vitro (IC50 = 5 nM) Activates NF-κB and MAPK pathways in human amnion via Gαi signaling, resulting in pro-inflammatory effects. Inhibits oxytocin-induced uterine contractions in vivo and in vitro. Effective in a rat preterm labor model.
Technical Data for Atosiban
| M. Wt | 994.19 |
| Formula | C43H67N11O12S2 |
| Sequence |
XYITNCPXG (Modifications: X-1 = Mpr, Tyr-2 = D-Tyr(OEt), X-8 = Orn, Gly-9 = C-terminal amide, Cyclized: X-1 - Cys-6) |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 90779-69-4 |
| PubChem ID | 5311010 |
| InChI Key | VWXRQYYUEIYXCZ-OBIMUBPZSA-N |
| Smiles | [H][C@@]1([C@H](O)C)NC(C([C@H](CC)C)NC([C@H](NC(CCSSC[C@@H](C(N2CCC[C@H]2C(N[C@H](C(NCC(N)=O)=O)CCCN)=O)=O)NC([C@@H](NC1=O)CC(N)=O)=O)=O)CC3=CC=C(C=C3)OCC)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Atosiban
| Solubility | Soluble to 50 mg/ml in water |
Product Datasheets for Atosiban
References for Atosiban
References are publications that support the biological activity of the product.
Kim et al (2016) The oxyt. receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via Gαi signalling. Mol.Cell.Endocrinol. 420 11 PMID: 26586210
Kim et al (2017) Differential effects of oxyt. receptor antagonists, Atosiban and Nolasiban, on oxyt. receptor-mediated signaling in human amnion and myometrium. Mol.Pharmacol. 91 403 PMID: 28188254
Hahn et al (1987) Evaluation of 1-deamino-[D-Tyr(Oethyl)2, Thr4, Orn8] vasotocin, an oxyt. antagonist, in animal models of uterine contractility and preterm labor: a new tocolytic agent. Am.J.Obstet.Gynecol. 157 977 PMID: 3674173
Maggi et al (1994) Antagonists for the human oxyt. receptor: an in vitro study. J.Reprod.Fertil. 101 345 PMID: 7932368
If you know of a relevant reference for Atosiban, please let us know.
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Keywords: Atosiban, Atosiban supplier, oxytoxin, receptor, antagonists, antagonism, tocolytics, preterm, labor, labour, OTR, Oxytocin, Receptors, 6332, Tocris Bioscience
4 Citations for Atosiban
Citations are publications that use Tocris products. Selected citations for Atosiban include:
Yoshiyuki et al (2020) Oxytocin-Dependent Regulation of TRPs Expression in Trigeminal Ganglion Neurons Attenuates Orofacial Neuropathic Pain Following Infraorbital Nerve Injury in Rats. Int J Mol Sci 21 PMID: 33271955
Li et al (2021) Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation Cell Rep 36 109411 PMID: 34289348
Xiaobing et al (2021) Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology 46 1045-1056 PMID: 33495546
Silke et al (2022) Oxytocin accelerates tight junction formation and impairs cellular migration in 3D spheroids: evidence from Gapmer-induced exon skipping. Front Cell Neurosci 16 1000538 PMID: 36263085
Do you know of a great paper that uses Atosiban from Tocris? Please let us know.
Reviews for Atosiban
Average Rating: 5 (Based on 1 Review.)
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Inhibition of oxytocin receptor.
By
Mohammad Alqudah on 10/19/2022
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Smooth muscle
10 uM of atosiban 10 to 15 min in an organ bath to block oxytocin-induced contraction of gut smooth muscle strips
