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Submit ReviewAvasimibe
Description: ACAT inhibitor
Chemical Name: 2,6-Diisopropylphenyl (2-(2,4,6-triisopropylphenyl)acetyl)sulfamate
Purity: ≥98% (HPLC)
Biological Activity for Avasimibe
Avasimibe is an ACAT inhibitor (IC50 = 3.3 μM). Inhibits cholesterol esterification and reduces plasma cholesterol levels in rats. Also inhibits tumor growth and prolongs survival time in a melanoma mouse model and reduces tumor growth and metastasis in a pancreatic cancer mouse model.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for Avasimibe
Avasimibe is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Avasimibe
| M. Wt | 501.72 |
| Formula | C29H43NO4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 166518-60-1 |
| PubChem ID | 166558 |
| InChI Key | PTQXTEKSNBVPQJ-UHFFFAOYSA-N |
| Smiles | CC(C1=CC(C(C)C)=C(C(C(C)C)=C1)CC(NS(=O)(OC2=C(C(C)C)C=CC=C2C(C)C)=O)=O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Avasimibe
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.17 | 100 | |
| ethanol | 10.03 | 20 |
Preparing Stock Solutions for Avasimibe
The following data is based on the product molecular weight 501.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.99 mL | 9.97 mL | 19.93 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.99 mL |
| 10 mM | 0.2 mL | 1 mL | 1.99 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets for Avasimibe
References for Avasimibe
References are publications that support the biological activity of the product.
Lee et al (1996) Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets. J.Med.Chem. 39 5031 PMID: 8978833
Yang et al (2016) Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism. Nature 531 651 PMID: 26982734
Li et al (2016) Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer. Oncogene 35 6378 PMID: 27132508
If you know of a relevant reference for Avasimibe, please let us know.
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Keywords: Avasimibe, Avasimibe supplier, CI-1011, ACAT, inhibits, inhibitors, acyl-CoA:cholesterol, O-acyl, transferase, antitumor, Acyl-CoAcholesterol, acyltransferase, Acyl-CoA:Cholesterol, Acyltransferase, 6505, Tocris Bioscience
Citations for Avasimibe
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Currently there are no citations for Avasimibe. Do you know of a great paper that uses Avasimibe from Tocris? Please let us know.
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