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Submit ReviewAZD 1283
Description: High affinity P2Y12 antagonist
Chemical Name: Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate
Purity: ≥98% (HPLC)
Biological Activity for AZD 1283
AZD 1283 is a potent and high affinity P2Y12 antagonist (IC50 = 11 nM in radioligand competition binding assay, and 25 nM in a GTPγS binding assay). Causes a dose-dependent increase in blood flow and inhibits ADP-induced platelet aggregation in vivo. Antithrombotic.
Compound Libraries for AZD 1283
AZD 1283 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for AZD 1283
| M. Wt | 470.54 |
| Formula | C23H26N4O5S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 919351-41-0 |
| PubChem ID | 23649325 |
| InChI Key | NEMHKCNXXRQYRF-UHFFFAOYSA-N |
| Smiles | CCOC(C1=CC(C#N)=C(N2CCC(C(NS(=O)(CC3=CC=CC=C3)=O)=O)CC2)N=C1C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AZD 1283
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.05 | 100 |
Preparing Stock Solutions for AZD 1283
The following data is based on the product molecular weight 470.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.63 mL | 21.25 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.25 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
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Product Datasheets for AZD 1283
References for AZD 1283
References are publications that support the biological activity of the product.
Bach et al (2013) Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J.Med.Chem. 56 7015 PMID: 23899349
Zhang et al (2014) Agonist-bound structure of the human P2Y12 receptor. Nature 509 119 PMID: 24784220
Zhang et al (2014) Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature 509 115 PMID: 24670650
If you know of a relevant reference for AZD 1283, please let us know.
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Keywords: AZD 1283, AZD 1283 supplier, AZD1283, High, affinity, p2y12, purine, receptors, antagonists, purinoceptors, purinergic, antagonises, inhibitors, inhibits, Purinergic, P2Y, Receptors, 6085, Tocris Bioscience
Citations for AZD 1283
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Currently there are no citations for AZD 1283. Do you know of a great paper that uses AZD 1283 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.