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Submit Reviewβ-Funaltrexamine hydrochloride
Discontinued Product
0926 has been discontinued.
Description: Irreversible and selective μ antagonist
Alternative Names: β-FNA
Chemical Name: (E)-4-[[5α,6β)-17-Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]amino]-4-oxo-2-butenoicacid methyl ester hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for β-Funaltrexamine hydrochloride
β-Funaltrexamine hydrochloride is a selective μ opioid receptor antagonist.
Licensing Information
Sold with the permission of the University of Minnesota
Technical Data for β-Funaltrexamine hydrochloride
| M. Wt | 490.99 |
| Formula | C25H30N2O6.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 72786-10-8 |
| PubChem ID | 44522395 |
| InChI Key | BIPHUOBUKMPSQR-NQGXHZAGSA-N |
| Smiles | Cl.[H][C@@]12OC3=C4C(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC[C@H]2NC(=O)\C=C\C(=O)OC)=CC=C3O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for β-Funaltrexamine hydrochloride
References for β-Funaltrexamine hydrochloride
References are publications that support the biological activity of the product.
Jiang et al (1990) μ Antagonist and κ agonist properties of β-funaltrexamine (β-FNA) in vivo: long lasting spinal analgesia in mice. J.Pharmacol.Exp.Ther. 252 1006 PMID: 2156986
Takemorei et al (1981) The irreversible narcotic antagonist and reversible agonist properties of the fumarate methyl ester derivative of naltr. Eur.J.Pharmacol. 70 445 PMID: 6263637
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7 Citations for β-Funaltrexamine hydrochloride
Citations are publications that use Tocris products. Selected citations for β-Funaltrexamine hydrochloride include:
Crowley et al (2020) Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the μ Opioid Receptor. ACS Chem Neurosci 11 1781 PMID: 32383854
Phillips et al (2012) Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression. J Neurophysiol 108 2393 PMID: 22956800
Largent-Milnes et al (2010) Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. Br J Pharmacol 161 986 PMID: 20977451
Chen et al (2015) Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. Neuropsychopharmacology 10 e0145556 PMID: 26700862
Tzeng et al (2011) Myricetin Ameliorates Defective Post-Receptor Ins Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats. Evid Based Complement Alternat Med 2011 150752 PMID: 21785619
Cecchi et al (2008) Differential responses to morphine-induced analgesia in the tail-flick test. Behav Brain Res 194 146 PMID: 18656501
Romero-Picó et al (2013) Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin. Circulation 38 1296 PMID: 23348063
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