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Submit Reviewβ-GalNAc-PEG4-Azide
Description: Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry
Chemical Name: 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2-(acetylamino)-2-deoxy-β-D-galactopyranoside
Purity: ≥95% (HPLC)
Biological Activity for β-GalNAc-PEG4-Azide
β-GalNAc-PEG4-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates a single ASGPR ligand with a PEG4 linker and azide group reactive handle ready for conjugation. It can be used as a building block for multivalent compounds to enhance ASGPR binding. Upon binding to ASGPR, β-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. β-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.
Usage Guidelines for β-GalNAc-PEG4-Azide
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for β-GalNAc-PEG4-Azide
| M. Wt | 422.44 |
| Formula | C16H30N4O9 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 879004-92-9 |
| PubChem ID | 129115265 |
| InChI Key | DWQAFMMYPUXSPI-IBEHDNSVSA-N |
| Smiles | [N-]=[N+]=NCCOCCOCCOCCO[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)CO)O)O)NC(C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for β-GalNAc-PEG4-Azide
References for β-GalNAc-PEG4-Azide
References are publications that support the biological activity of the product.
Sanhueza et al (2017) Efficient liver targeting by polyvalent display of a compact ligand for the asialoglycoprotein receptor. J.Am.Chem.Soc. 139 3528 PMID: 28230359
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Citations for β-GalNAc-PEG4-Azide
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TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia