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Submit Review[bAla8]-Neurokinin A(4-10)
Description: NK2 agonist
Alternative Names: MEN 10210
Biological Activity for [bAla8]-Neurokinin A(4-10)
[bAla8]-Neurokinin A(4-10) is a NK2 receptor agonist (pD2 = 6.91). Produces bladder contraction and bronchospasm in guinea pigs in vivo.
Technical Data for [bAla8]-Neurokinin A(4-10)
| M. Wt | 780.93 |
| Formula | C35H56N8O10S |
| Sequence |
DSFVALM (Modifications: Ala-5 = β-Ala, Met-7 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 122063-01-8 |
| PubChem ID | 9987795 |
| InChI Key | CKNPSJOMUQBPLA-WTWMNNMUSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NCCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for [bAla8]-Neurokinin A(4-10)
References for [bAla8]-Neurokinin A(4-10)
References are publications that support the biological activity of the product.
Carini et al (2001) Tachykinin NK2 receptors and enhancement of cholinergic transmission in the inflamed rat colon: an in vivo motility study. Br.J.Pharmacol. 133 1107 PMID: 11487522
Maggi et al (1990) In vivo pharmacology of [βAla8]neurokinin A-(4-10), a selective NK-2 tachykinin receptor agonist. Eur.J.Pharmacol. 177 81 PMID: 2160369
Rovero et al (1989) A potent and selective agonist for NK-2 tachykinin receptor. Peptides 10 593 PMID: 2550911
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Keywords: [bAla8]-Neurokinin A(4-10), [bAla8]-Neurokinin A(4-10) supplier, NK2, agonists, Tachykinin, Receptors, Neurokinin, MEN10210, MEN, 10210, Receptor, 1640, Tocris Bioscience
1 Citation for [bAla8]-Neurokinin A(4-10)
Citations are publications that use Tocris products. Selected citations for [bAla8]-Neurokinin A(4-10) include:
Cavalcanti-de-Albuquerque et al (2019) Regulation of substrate utilization and adiposity by Agrp neurons. Nat Commun 10 311 PMID: 30659173
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Literature in this Area
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