Home / Pharmacology / Transporters / Ion Pumps/Transporters / Monocarboxylate Transporters / Monocarboxylate Transporter Inhibitors / BAY 8002

BAY 8002

Cat. No. 6817 1 Citation Submit a Review Datasheet / COA / SDS

Discontinued Product

6817 has been discontinued.

View all Monocarboxylate Transporters products.
Description: Potent dual MCT1/2 inhibitor; orally bioavailable
Chemical Name: 2-[[2-Chloro-5-(phenylsulfonyl)benzoyl]amino]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Datasheets References

Biological Activity for BAY 8002

BAY 8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3, 8, and 12 nM at rat (C6), human (DLD-1) and mouse (4T1) MCT1 respectively; IC50 values of human MCT1, MCT2, and MCT4 isoforms recombinantly expressed in X. laevis oocytes are 1, 5 and >500 nM, respectively); suppresses bidirectional lactate transport. Inhibits cellular SNARF-5 fluorescence change (IC50 = 85 nM) in MCT1-expressing DLD-1 cells. Arrests growth and increases intratumor lactate levels of Raji tumor xenografts in mice. Orally bioavailable.

Technical Data for BAY 8002

M. Wt 415.85
Formula C20H14ClNO5S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 724440-27-1
PubChem ID 992293
InChI Key CLAUJSRBKSRTGQ-UHFFFAOYSA-N
Smiles OC(C1=C(C=CC=C1)NC(C2=C(C=CC(S(=O)(C3=CC=CC=C3)=O)=C2)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for BAY 8002

References are publications that support the biological activity of the product.

Quanz et al (2018) Preclinical efficacy of the novel monocarboxylate transporter 1 inhibitor BAY-8002 and associated markers of resistance. Mol.Cancer Ther. 17 2285 PMID: 30115664

View Related Products by Target

View Related Products by Product Action

View all Monocarboxylate Transporter Inhibitors

Keywords: BAY 8002, BAY 8002 supplier, BAY8002, potent, dual, MCT1/2, inhibitors, inhibits, MCT1, MCT2, orally, bioavailable, lactate, Monocarboxylate, Transporters, 6817, Tocris Bioscience

1 Citation for BAY 8002

Citations are publications that use Tocris products. Selected citations for BAY 8002 include:

Keit Men et al (2020) A glycolytic shift in Schwann cells supports injured axons. Nat Neurosci 23 1215-1228 PMID: 32807950

Reviews for BAY 8002

There are currently no reviews for this product. Be the first to review BAY 8002 and earn rewards!

Have you used BAY 8002?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.