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Submit ReviewBC 11-38
Description: Selective PDE11 inhibitor
Chemical Name: 6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)one
Purity: ≥98% (HPLC)
Biological Activity for BC 11-38
BC 11-38 is a selective phosphodiesterase (PDE) 11 inhibitor (IC50 = 0.28 μM for PDE11; IC50 values are >100 μM for PDE1 - PDE10). Significantly elevates cAMP levels and cortisol production in H295R human adenocarcinoma cells.
Technical Data for BC 11-38
| M. Wt | 304.43 |
| Formula | C15H16N2OS2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 686770-80-9 |
| PubChem ID | 2052828 |
| InChI Key | YHNDCCKFNWDQGW-UHFFFAOYSA-N |
| Smiles | CCCSC1=NC(CCS3)=C3C(N1C2=CC=CC=C2)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BC 11-38
References for BC 11-38
References are publications that support the biological activity of the product.
Ceyhan et al (2012) Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem.Biol. 19 155 PMID: 22284362
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Keywords: BC 11-38, BC 11-38 supplier, BC11-38, phosphodiesterase, pde, 11, inhibitors, inhibits, selective, Phosphodiesterases, 4496, Tocris Bioscience
1 Citation for BC 11-38
Citations are publications that use Tocris products. Selected citations for BC 11-38 include:
Lu and Sewer (2015) p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation. J Biol Chem 35 1223 PMID: 25605330
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