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Submit ReviewBeraprost sodium
Description: Potent prostacyclin IP receptor agonist
Chemical Name: rel-(1R,2R,3aS,8bS)-2,3,3a,8b-Tetrahydro-2-hydroxy-1-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl)-1H-cyclopenta[b]benzofuran-5-butanoic acid sodium salt
Purity: ≥98% (HPLC)
Biological Activity for Beraprost sodium
Beraprost sodium is a potent IP receptor agonist; analog of Epoprostenol (Cat. No. 2989). Potently inhibits ADP-induced platelet aggregation and P-selectin expression in vitro (pIC50 values are 8.26 and 8.56, respectively). Also increases vasodilation and reduces pulmonary hypertension in vivo. Orally active.
Technical Data for Beraprost sodium
| M. Wt | 420.47 |
| Formula | C24H29NaO5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 496807-11-5 |
| PubChem ID | 23663404 |
| InChI Key | JLHRLDZCMGGIKW-OQNJEIHKSA-M |
| Smiles | O[C@@H]1C[C@H]2[C@H](C(C=CC=C3CCCC(O[Na])=O)=C3O2)[C@H]1/C=C/[C@@H](O)C(C)CC#CC.O[C@H]4C[C@@H]5[C@@H](C(C=CC=C6CCCC(O[Na])=O)=C6O5)[C@@H]4/C=C/[C@H](O)C(C)CC#CC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Beraprost sodium
References for Beraprost sodium
References are publications that support the biological activity of the product.
Miyamoto et al (2003) Effects of TRA-418, a novel TP-receptor antagonist, and IP-receptor agonist, on human platelet activation and aggregation. Br.J.Pharmacol. 140 889 PMID: 14504133
Saito et al (1995) Effects of beraprost sodium (a PGI2 derivative) on chronic hypoxic pulmonary hypertension in the rat. Nihon Kyobu Shikkan Gakkai Zasshi. 33 497 PMID: 7609334
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Keywords: Beraprost sodium, Beraprost sodium supplier, Prostacyclin, IP, receptor, agonists, pulmonary, hypertension, vasodilation, platelet, aggregation, 88475-69-8, Prostanoid, Receptors, 4180, Tocris Bioscience
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