Home / Pharmacology / Enzymes / Polymerases / Poly(ADP-ribose) Polymerase / Poly(ADP-Ribose) Polymerase Inhibitors / BGP 15

BGP 15

Cat. No. 6703 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: PARP inhibitor; cytoprotectant
Chemical Name: N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BGP 15

BGP 15 is a PARP inhibitor (IC50 = 120 μM). Displays cytoprotective effects in various disease models: decreases ROS levels, lipid peroxidation and single-strand DNA breaks in isolated reperfused rat hearts; improves mitochondrial function and protects against neuronal cell death in a mouse model of familial dysautonomia. BGP 15 also activates HSP70 in rodent skeletal muscle, increasing oxidative capacity and improving insulin sensitivity.

Technical Data for BGP 15

M. Wt 351.27
Formula C14H22N4O2.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 66611-37-8
PubChem ID 70701185
InChI Key ISGGVCWFTPTHIX-UHFFFAOYSA-N
Smiles OC(CN1CCCCC1)CONC(C2=CN=CC=C2)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BGP 15

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.03 20 with gentle warming
water 35.13 100

Preparing Stock Solutions for BGP 15

The following data is based on the product molecular weight 351.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.47 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for BGP 15

References are publications that support the biological activity of the product.

Szabados et al (2000) BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase. Biochem.Pharmacol. 59 937 PMID: 10692558

Racz et al (2002) BGP-15 - a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity. Biochem.Pharmacol. 63 1099 PMID: 11931842

Henstridge et al (2014) Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance. Diabetes. 63 1881 PMID: 24430435

Ohlen et al (2017) BGP-15 prevents the death of neurons in a mouse model of familial dysautonomia. Proc.Natl.Acad.Sci.U.S.A 114 5035 PMID: 28439028

Chung et al (2008) HSP72 protects against obesity-induced insulin resistance. Proc.Natl.Acad.Sci.U.S.A 105 1739 PMID: 18223156

If you know of a relevant reference for BGP 15, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Poly(ADP-Ribose) Polymerase Inhibitors

Keywords: BGP 15, BGP 15 supplier, BGP15, cytoprotectant, chemoprotectant, PARP, inhibitors, inhibits, Hsp70, protein, 1, Hsp72, activators, activates, Poly(ADP-ribose), Polymerase, 6703, Tocris Bioscience

Citations for BGP 15

Citations are publications that use Tocris products.

Currently there are no citations for BGP 15. Do you know of a great paper that uses BGP 15 from Tocris? Please let us know.

Reviews for BGP 15

There are currently no reviews for this product. Be the first to review BGP 15 and earn rewards!

Have you used BGP 15?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.