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BI-6901

Cat. No. 6141 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective CCR10 antagonist
Chemical Name: N-[(1R)-3-(2-Cyano-1H-pyrrol-1-yl)-1-[(4-methyl-1-piperidinyl)carbonyl]propyl]-1H-indole-4-sulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BI-6901

BI-6901 is a potent and selective CCR10 antagonist (IC50 = 1 - 25 nM). BI-6901 inhibits CCL27-dependent chemotaxis of Ba/F3 cells (IC50 = 1 nM) and reduces inflammation in a DNFB-stimulated animal model of contact hypersensitivity.

Technical Data for BI-6901

M. Wt 453.56
Formula C23H27N5O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2040401-92-9
PubChem ID 131801164
InChI Key BRJXJOWXAFLRTE-OAQYLSRUSA-N
Smiles CC1CCN(C([C@H](NS(=O)(C2=C3C=CNC3=CC=C2)=O)CCN4C=CC=C4C#N)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BI-6901

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.36 100
ethanol 45.36 100

Preparing Stock Solutions for BI-6901

The following data is based on the product molecular weight 453.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 11.02 mL 22.05 mL
5 mM 0.44 mL 2.2 mL 4.41 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References for BI-6901

References are publications that support the biological activity of the product.

Abeywardane et al (2016) N-Arylsulfonyl-a-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg.Med.Chem.Lett. 26 5277 PMID: 27692854

If you know of a relevant reference for BI-6901, please let us know.

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Citations for BI-6901

Citations are publications that use Tocris products.

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Literature in this Area

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Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

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