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Description: DR5 (TRAIL receptor) agonist; induces apoptosis
Chemical Name: 5-[5-[[(5Z)-3-(4-Bromophenyl)-2-imino-4-oxo-5-thiazolidinylidene]methyl]-2-furanyl]-1H-isoindole-1,3(2H)-dione
Purity: ≥97% (HPLC)
Biological Activity for Bioymifi
Bioymifi is a DR5 (TRAIL receptor) agonist. Directly binds extracellular domain of DR5 (Kd = 1.2 μM) and induces the formation of DR5 aggregates. Induces apoptosis of glioblastoma cells.
Technical Data for Bioymifi
| M. Wt | 494.32 |
| Formula | C22H12BrN3O4S |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1420071-30-2 |
| PubChem ID | 70678419 |
| InChI Key | ULBOWKXOFOTCMU-NLDKGBHCSA-N |
| Smiles | BrC1=CC=C(N3C(/C(SC3=N)=C/C2=CC=C(C4=CC=C(C(NC5=O)=O)C5=C4)O2)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Bioymifi
References for Bioymifi
References are publications that support the biological activity of the product.
Wang et al (2013) Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat.Chem.Biol. 9 84 PMID: 23292651
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Keywords: Bioymifi, Bioymifi supplier, TRAIL, tumor, necrosis, factor-related, apoptosis-inducing, ligand, DR5, TNF, agonists, agonism, Cytokine, Receptors, Apoptosis, Inducers, 5372, Tocris Bioscience
Citations for Bioymifi
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