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Submit ReviewBIRB 796
Description: High affinity and selective p38 kinase inhibitor
Alternative Names: Doramapimod
Chemical Name: N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea
Purity: ≥98% (HPLC)
Biological Activity for BIRB 796
BIRB 796 is a high affinity and selective p38 kinase inhibitor (Kd = 50-100 pM). Exhibits no significant inhibition on a panel of related kinases. Inhibits LPS-induced TNFα production in human PBMCs and whole blood (IC50 values are 21 and 960 nM, respectively). Also inhibits JNK2α2 and c-Raf-1 (IC50 values are 98 nM and 1.4 μM, respectively). BIRB 796 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs. Cell permeable.
Compound Libraries for BIRB 796
BIRB 796 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for BIRB 796
| M. Wt | 527.66 |
| Formula | C31H37N5O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 285983-48-4 |
| PubChem ID | 156422 |
| InChI Key | MVCOAUNKQVWQHZ-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(N2N=C(C(C)(C)C)C=C2NC(NC3=CC=C(C4=C3C=CC=C4)OCCN5CCOCC5)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BIRB 796
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.28 | 10 |
Preparing Stock Solutions for BIRB 796
The following data is based on the product molecular weight 527.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.95 mL | 94.76 mL | 189.52 mL |
| 0.5 mM | 3.79 mL | 18.95 mL | 37.9 mL |
| 1 mM | 1.9 mL | 9.48 mL | 18.95 mL |
| 5 mM | 0.38 mL | 1.9 mL | 3.79 mL |
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Product Datasheets for BIRB 796
References for BIRB 796
References are publications that support the biological activity of the product.
Laufer et al (2008) Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region. J.Med.Chem. 51 4122 PMID: 18578517
Regan et al (2003) Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796). J.Med.Chem. 46 4676 PMID: 14561087
Goldstein et al (2010) Selective p38α inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J.Med.Chem. 53 2345 PMID: 19950901
Kuma et al (2005) BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. J.Biol.Chem. 280 19472 PMID: 15755732
Guan et al (2022) Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 605 325 PMID: 35418683
If you know of a relevant reference for BIRB 796, please let us know.
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12 Citations for BIRB 796
Citations are publications that use Tocris products. Selected citations for BIRB 796 include:
Shyni et al (2022) An In Vitro Microfluidic Alveolus Model to Study Lung Biomechanics. Front Bioeng Biotechnol 10 848699 PMID: 35252157
Aleksandra et al (2022) Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures. STAR Protoc 3 101447 PMID: 35712012
Lucie et al (2022) Regulation of Stress-Activated Kinases in Response to Tacaribe Virus Infection and Its Implications for Viral Replication. Viruses 14 PMID: 36146824
Richard C et al (2022) Human distal lung maps and lineage hierarchies reveal a bipotent progenitor. Nature 604 111-119 PMID: 35355018
Simon et al (2022) Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response. Cell Metab 34 2036-2046.e8 PMID: 36384144
Crozier et al (2023) CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence. Mol.Cell 83 4062 PMID: 37977118
Markus et al (2021) p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway. Cell Stress 5 176-182 PMID: 34917890
Harold A et al (2020) Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration. Cell Stem Cell 26 346-358.e4 PMID: 31978363
Richard C et al (2020) Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction. Cell Stem Cell 27 890-904.e8 PMID: 33128895
Stephen J et al (2019) Clinically Advanced p38 Inhibitors Suppress DUX4 Expression in Cellular and Animal Models of Facioscapulohumeral Muscular Dystrophy. J Pharmacol Exp Ther 370 219-230 PMID: 31189728
Michel et al (2019) Acute inflammation down-regulates alpha-synuclein expression in enteric neurons. J Neurochem 148 746-760 PMID: 30589944
Singh et al (2018) Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro. Hum Exp Toxicol 37 521 PMID: 28629242
Do you know of a great paper that uses BIRB 796 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for BIRB 796
