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Submit ReviewBIX NHE1 inhibitor
Description: Potent and selective NHE1 inhibitor
Chemical Name: 4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for BIX NHE1 inhibitor
BIX NHE1 inhibitor is a potent and selective NHE1 inhibitor (IC50 = 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo. Prevents phenylephrine-induced cardiomyocyte hypertrophy in vitro, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable.
Technical Data for BIX NHE1 inhibitor
| M. Wt | 392.8 |
| Formula | C16H19F3N4O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1422252-46-7 |
| PubChem ID | 121513866 |
| InChI Key | SLSZLEROFKLICF-UHFFFAOYSA-N |
| Smiles | CC(N(CC2)CCC2C1=C(C(F)(F)F)C=C(C(NC(N)=N)=O)C=C1)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BIX NHE1 inhibitor
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.64 | 50 |
Preparing Stock Solutions for BIX NHE1 inhibitor
The following data is based on the product molecular weight 392.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.09 mL | 25.46 mL | 50.92 mL |
| 2.5 mM | 1.02 mL | 5.09 mL | 10.18 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.09 mL |
| 25 mM | 0.1 mL | 0.51 mL | 1.02 mL |
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Product Datasheets for BIX NHE1 inhibitor
References for BIX NHE1 inhibitor
References are publications that support the biological activity of the product.
Kilić et al (2014) Early and transient sodium-hydrogen exchanger isoform 1 inhibition attenuates subsequent cardiac hypertrophy and heart failure following coronary artery ligation. J.Pharmacol.Exp.Ther. 351 492 PMID: 25216745
Huber et al (2012) Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. J.Med.Chem. 55 7114 PMID: 22803959
If you know of a relevant reference for BIX NHE1 inhibitor, please let us know.
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Keywords: BIX NHE1 inhibitor, BIX NHE1 inhibitor supplier, BIXNHE1, inhibitor, sodium, hydrogen, exchanger, isoform1, inhibitors, inhibits, potent, selective, hypertrophy, ischemia, Na+/H+, Exchanger, 5512, Tocris Bioscience
1 Citation for BIX NHE1 inhibitor
Citations are publications that use Tocris products. Selected citations for BIX NHE1 inhibitor include:
Valerie M et al (2021) Adhesion-mediated mechanosignaling forces mitohormesis. Cell Metab 33 1322-1341.e13 PMID: 34019840
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