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Submit ReviewBMS 265246
Description: Cdk inhibitor; potently inhibits cdk1 and cdk2
Chemical Name: (4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl) (2,6-difluoro-4-methylphenyl)methanone
Purity: ≥97% (HPLC)
Biological Activity for BMS 265246
BMS 265246 is a potent cyclin-dependent kinase 1 (cdk1) and cdk 2 inhibitor (IC50 values are 5.6 - 71 and 6 - 14 nM, respectively). Also inhibits cdk4 and cdk5 in the sub micromolar range and cdk7 and cdk9 in the low micromolar range. Inhibits proliferation of HCT-116 colon cancer cells in vitro.
External Portal Information for BMS 265246
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMS-265246 is reviewed on the chemical probes website.
Compound Libraries for BMS 265246
BMS 265246 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
Technical Data for BMS 265246
| M. Wt | 345.34 |
| Formula | C18H17F2N3O2 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 582315-72-8 |
| PubChem ID | 5329775 |
| InChI Key | SCFMWQIQBVZOQR-UHFFFAOYSA-N |
| Smiles | CCCCOC1=C2C=NNC2=NC=C1C(C3=C(C=C(C=C3F)C)F)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BMS 265246
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.27 | 50 |
Preparing Stock Solutions for BMS 265246
The following data is based on the product molecular weight 345.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.79 mL | 28.96 mL | 57.91 mL |
| 2.5 mM | 1.16 mL | 5.79 mL | 11.58 mL |
| 5 mM | 0.58 mL | 2.9 mL | 5.79 mL |
| 25 mM | 0.12 mL | 0.58 mL | 1.16 mL |
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Product Datasheets for BMS 265246
References for BMS 265246
References are publications that support the biological activity of the product.
Misra et al (2003) 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. Bioorg.Med.Chem.Lett. 13 2405 PMID: 12824044
Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987
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Keywords: BMS 265246, BMS 265246 supplier, BMS265246, potent, cyclin, dependent, kinases, cdk1, cdk2, inhibitors, inhibits, Cyclin-dependent, Kinase, Non-selective, CDKs, 5654, Tocris Bioscience
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