Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewBMS 303141
Description: ATP citrate lyase inhibitor; orally bioavailable
Chemical Name: 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for BMS 303141
BMS 303141 is an ATP citrate lyase (ACL) inhibitor (IC50 = 0.13 μM for human recombinant ACL); blocks lipid synthesis (IC50 = 8 μM in HepG2 cells). Displays no cytotoxicity up to a concentration of 50 μM. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia; reduces cell proliferation in HepG2 and Huh-7 cell lines and in PD-1 deficient lymphomas. Orally bioavailable.
Technical Data for BMS 303141
| M. Wt | 424.3 |
| Formula | C19H15Cl2NO4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 943962-47-8 |
| PubChem ID | 90488956 |
| InChI Key | LIZVMVYXZWADCK-UHFFFAOYSA-N |
| Smiles | ClC1=CC(Cl)=C(O)C=C1S(NC2=C(C3=CC=CC=C3)C=CC(OC)=C2)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BMS 303141
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.24 | 10 | |
| ethanol | 21.21 | 50 |
Preparing Stock Solutions for BMS 303141
The following data is based on the product molecular weight 424.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.71 mL | 23.57 mL | 47.14 mL |
| 2.5 mM | 0.94 mL | 4.71 mL | 9.43 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.71 mL |
| 25 mM | 0.09 mL | 0.47 mL | 0.94 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for BMS 303141
References for BMS 303141
References are publications that support the biological activity of the product.
Li et al (2007) 2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorg.Med.Chem.Lett. 17 3208 PMID: 17383874
Ma et al (2009) A novel direct homogeneous assay for ATP citrate lyase. J.Lipid Res. 50 2131 PMID: 19286649
Wartewig et al (2023) PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma. Nat.Cancer 4 1508 PMID: 37723306
If you know of a relevant reference for BMS 303141, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: BMS 303141, BMS 303141 supplier, BMS303141, ATP, citrate, lyases, inhibits, inhibitors, plasma, glucose, triglycerides, orally, bioavailable, synthases, transferases, ACLY, immunometabolism, Citrate, Lyase, 4609, Tocris Bioscience
9 Citations for BMS 303141
Citations are publications that use Tocris products. Selected citations for BMS 303141 include:
Márquez et al (2019) Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns. Cell Rep 27 525 PMID: 30970255
Shah et al (2016) Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism. Oncotarget 7 43713 PMID: 27248322
Bernhard et al (2022) Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells. Front Immunol 13 906127 PMID: 36439127
Lars et al (2020) Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells. Front Immunol 11 1968 PMID: 32849657
Dong et al (2020) Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation. Nat Commun 11 3806 PMID: 32732922
Namgaladze et al (2018) Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase. Front Immunol 9 2858 PMID: 30568658
Wartewig et al (2023) PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma. Nat.Cancer 4 1508 PMID: 37723306
Catherine A et al (2021) Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation. Nat Commun 12 1209 PMID: 33619282
Douglas R et al (2021) Polyamine metabolism is a central determinant of helper T cell lineage fidelity. Cell 184 4186-4202.e20 PMID: 34216540
Do you know of a great paper that uses BMS 303141 from Tocris? Please let us know.
Reviews for BMS 303141
There are currently no reviews for this product. Be the first to review BMS 303141 and earn rewards!
Have you used BMS 303141?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image