Home / Pharmacology / Transporters / Ion Pumps/Transporters / Other Ion Pumps/Transporters / Other Ion Pumps/Transporter Inhibitors / BMS 466442

BMS 466442

Cat. No. 6878 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective inhibitor of asc-1
Chemical Name: N-[[5-Methoxy-6-(phenylmethoxy)-1H-indol-2-yl]carbonyl]-1-(phenylmethyl)-L-histidine methyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BMS 466442

BMS 466442 is a potent and selective asc-1 (alanine-serine-cysteine-1) transporter inhibitor (IC50 values are 20 and 37 nM in rat primary cortical cultures and HEK cells expressing asc-1 respectively). Displays >1000-fold selectivity for asc-1 over LAT-2 and ASCT-2. This compound is unsuitable for in vivo studies.

Technical Data for BMS 466442

M. Wt 538.6
Formula C31H30N4O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1598424-76-0
PubChem ID 124082063
InChI Key UUCAHZCMRZOTNF-MHZLTWQESA-N
Smiles COC(=O)[C@H](CC1=CN(CC2=CC=CC=C2)C=N1)NC(=O)C1=CC2=CC(OC)=C(OCC3=CC=CC=C3)C=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BMS 466442

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.86 100

Preparing Stock Solutions for BMS 466442

The following data is based on the product molecular weight 538.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.28 mL 18.57 mL
5 mM 0.37 mL 1.86 mL 3.71 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for BMS 466442

References are publications that support the biological activity of the product.

Torrecillas et al (2019) Inhibition of the alanine-serine-cysteine-1 transporter by BMS-466442. ACS Chem.Neurosci. 10 2510 PMID: 30821959

Brown et al (2014) In vitro characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10). J.Neurochem. 129 275 PMID: 24266811

If you know of a relevant reference for BMS 466442, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Ion Pumps/Transporter Inhibitors

Keywords: BMS 466442, BMS 466442 supplier, BMS466442, potent, selective, asc-1, alanine-serine-cysteine-1, transporters, inhibitors, inhibits, SLC7A10, Other, Ion, Pumps/Transporters, 6878, Tocris Bioscience

Citations for BMS 466442

Citations are publications that use Tocris products.

Currently there are no citations for BMS 466442. Do you know of a great paper that uses BMS 466442 from Tocris? Please let us know.

Reviews for BMS 466442

There are currently no reviews for this product. Be the first to review BMS 466442 and earn rewards!

Have you used BMS 466442?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review