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BMS 688521

Cat. No. 4970 1 Citation Submit a Review Datasheet / COA / SDS
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Description: Potent inhibitor of the LFA-1/ICAM interaction
Chemical Name: 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BMS 688521

BMS 688521 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 2.5 and 78 nM in HUVEC adhesion and mouse specific adhesion assays respectively). Inhibits eosinophil accumulation in the lungs in a mouse allergic eosinophilic lung inflammation model.

Compound Libraries for BMS 688521

BMS 688521 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BMS 688521

M. Wt 536.37
Formula C26H19Cl2N5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 893397-44-9
PubChem ID 11699447
InChI Key LILGMDXLRPEBNH-HFZDXXHNSA-N
Smiles CN1C(=O)N(C(=O)[C@]11CN(C[C@H]1C1=CC=C(C=C1)C#N)C1=NC=C(C=C1)C(O)=O)C1=CC(Cl)=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BMS 688521

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.64 100

Preparing Stock Solutions for BMS 688521

The following data is based on the product molecular weight 536.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.32 mL 18.64 mL
5 mM 0.37 mL 1.86 mL 3.73 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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References for BMS 688521

References are publications that support the biological activity of the product.

Watterson et al (2010) Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4] J.Med.Chem. 53 3814 PMID: 20405922

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Keywords: BMS 688521, BMS 688521 supplier, BMS688521, LFA-1, antagonists, blocker, interaction, inhibitors, inhibits, ICAM1, lymphocyte, function, associated, antigen, intracellular, adhesion, molecule, potent, Integrins, Cell, Adhesion, Molecules, 4970, Tocris Bioscience

1 Citation for BMS 688521

Citations are publications that use Tocris products. Selected citations for BMS 688521 include:

Jing et al (2019) CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells. Cell Rep 28 2892-2904.e7 PMID: 31509750

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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