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Submit ReviewBMS 986094
Description: Inhibitor of HCV RNA-dependent RNA polymerase (RdRP; NS5b); potent hepatitis C virus (HCV) replication inhibitor
Alternative Names: INX 08189
Chemical Name: Neopentyl [[[(2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl]methoxy](naphthalen-1-yloxy)phosphoryl]-L-alaninate
Purity: ≥98% (HPLC)
Biological Activity for BMS 986094
BMS 986094 is a potent hepatitis C virus (HCV) replication inhibitor (EC50 = 35 nM). Is rapidly metabolized in primary human hepatocytes to 2'-C-methyl guanosine triphosphate, an inhibitor of HCV RNA-dependent RNA polymerase NS5b. Displays 10-fold reduction in potency in S282T mutant-expressing versus wild-type replicons. Exhibits synergy with Ribavirin (Cat. No. 4501). Orally bioavailable.
Technical Data for BMS 986094
| M. Wt | 658.65 |
| Formula | C30H39N6O9P |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1234490-83-5 |
| PubChem ID | 46700744 |
| InChI Key | YFXGICNMLCGLHJ-RSKRLRQZSA-N |
| Smiles | COC1=C2N=CN([C@@H]3O[C@H](CO[P](=O)(N[C@@H](C)C(=O)OCC(C)(C)C)OC4=CC=CC5=C4C=CC=C5)[C@@H](O)[C@@]3(C)O)C2=NC(N)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BMS 986094
References for BMS 986094
References are publications that support the biological activity of the product.
Vernachio et al (2011) INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties. Antimicrob.Agents Chemother. 55 1843 PMID: 21357300
McGuigan et al (2010) Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus. Bioorg.Med.Chem.Lett. 20 4850 PMID: 20637609
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