BOP

Cat. No. 6047 4 Citations Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs

Chemical Name: N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt

Purity: ≥98% (HPLC)

Datasheet

Citations (4)

Reviews

Literature (2)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BOP

BOP is a dual α9β1/α4β1 integrin inhibitor; rapidly and preferentially mobilizes HSCs and progenitors. Augments HSC mobilization in combination with AMD3100 (Cat. No. 3299).

Fluorogenic, bright and photostable Fluorescent Conjugate BOP-JF646 (Cat. No. 6997) also available.

High affinity fluorescent derivative R-BC154 (Cat. No. 6048) also available.

Compound Libraries for BOP

BOP is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for BOP

M. Wt	537.56
Formula	C₂₅H₂₈N₃O₇SNa
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1947348-42-6
PubChem ID	10301396
InChI Key	PNMINTLPFWMZKM-VROPFNGYSA-M
Smiles	O=C([C@@H](NC([C@@H]1CCCN1S(=O)(C2=CC=CC=C2)=O)=O)CC3=CC=C(C=C3)OC(N4CCCC4)=O)O[Na]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BOP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	53.76	100
	DMSO	53.76	100

Preparing Stock Solutions for BOP

The following data is based on the product molecular weight 537.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.3 mL	18.6 mL
5 mM	0.37 mL	1.86 mL	3.72 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

Product Datasheets for BOP

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for BOP

References are publications that support the biological activity of the product.

Cao et al (2014) Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org.Biomol.Chem. 12 965 PMID: 24363056

Pepinsky et al (2002) Comparative assessment of the ligand and metal ion binding properties of integrins α9β1 and α4β1. Biochemistry 41 7125 PMID: 12033947

Cao et al (2016) Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat.Commun. 7 11007 PMID: 26975966

If you know of a relevant reference for BOP, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Integrin Inhibitors

Keywords: BOP, BOP supplier, Dual, α9β/1α4β1, integrin, inhibitors, inhibits, rapidly, mobilizes, HSC, progenitors, hematopoietic, haematopoietic, stem, cells, Integrins, Cell, Adhesion, Molecules, Stem, Signaling, Hematopoietic, Cells, 6047, Tocris Bioscience

4 Citations for BOP

Citations are publications that use Tocris products. Selected citations for BOP include:

Uwe et al (2020) Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma. Cancer Immunol Res 8 1122-1138 PMID: 32665262

Upadhaya et al (2020) Intravital imaging reveals motility of adult hematopoietic stem cells in the bone marrow niche Cell Stem Cell 27 336 PMID: 32589864

Jingping et al (2021) Tenascin-C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression. EMBO Mol Med 13 e13270 PMID: 33988305

David R et al (2021) Plasma cell dynamics in the bone marrow niche. Cell Rep 34 108733 PMID: 33567286

Do you know of a great paper that uses BOP from Tocris? Please let us know.

Reviews for BOP

There are currently no reviews for this product. Be the first to review BOP and earn rewards!

Have you used BOP?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.

BOP