BRACO 19 trihydrochloride

Cat. No. 5312 Submit a Review Datasheet / COA / SDS

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Description: Telomerase inhibitor

Chemical Name: N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide trihydrochloride

Purity: ≥94% (HPLC)

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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BRACO 19 trihydrochloride

BRACO 19 trihydrochloride is a telomerase inhibitor (IC₅₀ = 115 nM). Inhibits expression of human telomerase reverse transcriptase (hTERT), induces cellular senescence and inhibits growth of uterine cancer cells in vitro. Inhibits growth of uterine tumor xenografts in mice.

Technical Data for BRACO 19 trihydrochloride

M. Wt	703.14
Formula	C₃₅H₄₃N₇O₂.3HCl
Storage	Store at -20°C
Purity	≥94% (HPLC)
CAS Number	1177798-88-7
PubChem ID	10349800
InChI Key	MJAPNWJRLLDPAB-UHFFFAOYSA-N
Smiles	O=C(CCN5CCCC5)NC3=CC2=NC1=CC(NC(CCN6CCCC6)=O)=CC=C1C(NC4=CC=C(N(C)C)C=C4)=C2C=C3.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BRACO 19 trihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	35.16	50
	DMSO	35.16	50

Preparing Stock Solutions for BRACO 19 trihydrochloride

The following data is based on the product molecular weight 703.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.84 mL	14.22 mL	28.44 mL
2.5 mM	0.57 mL	2.84 mL	5.69 mL
5 mM	0.28 mL	1.42 mL	2.84 mL
25 mM	0.06 mL	0.28 mL	0.57 mL

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Product Datasheets for BRACO 19 trihydrochloride

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for BRACO 19 trihydrochloride

References are publications that support the biological activity of the product.

Gowan et al (2002) A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol.Pharmacol. 61 1154 PMID: 11961134

Burger et al (2005) The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res. 15 1489 PMID: 15735037

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Citations for BRACO 19 trihydrochloride

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