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Submit ReviewBRACO 19 trihydrochloride
Description: Telomerase inhibitor
Chemical Name: N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide trihydrochloride
Purity: ≥94% (HPLC)
Biological Activity for BRACO 19 trihydrochloride
BRACO 19 trihydrochloride is a telomerase inhibitor (IC50 = 115 nM). Inhibits expression of human telomerase reverse transcriptase (hTERT), induces cellular senescence and inhibits growth of uterine cancer cells in vitro. Inhibits growth of uterine tumor xenografts in mice.
Technical Data for BRACO 19 trihydrochloride
| M. Wt | 703.14 |
| Formula | C35H43N7O2.3HCl |
| Storage | Store at -20°C |
| Purity | ≥94% (HPLC) |
| CAS Number | 1177798-88-7 |
| PubChem ID | 10349800 |
| InChI Key | MJAPNWJRLLDPAB-UHFFFAOYSA-N |
| Smiles | O=C(CCN5CCCC5)NC3=CC2=NC1=CC(NC(CCN6CCCC6)=O)=CC=C1C(NC4=CC=C(N(C)C)C=C4)=C2C=C3.Cl.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BRACO 19 trihydrochloride
References for BRACO 19 trihydrochloride
References are publications that support the biological activity of the product.
Gowan et al (2002) A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol.Pharmacol. 61 1154 PMID: 11961134
Burger et al (2005) The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res. 15 1489 PMID: 15735037
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