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Submit ReviewBRD 6989
Description: Cdk8 inhibitor; enhances IL-10 production
Chemical Name: 2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile
Purity: ≥97% (HPLC)
Biological Activity for BRD 6989
Binds and inhibits Cdk8 in complex with cyclin C (IC50 ~ 200 nM). Enhances IL-10 production in activated human and murine macrophages and dendritic cells (EC50 is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Also inhibits CDK19 in complex with cyclin C.
Compound Libraries for BRD 6989
BRD 6989 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for BRD 6989
| M. Wt | 264.33 |
| Formula | C16H16N4 |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 642008-81-9 |
| PubChem ID | 3835861 |
| InChI Key | QSYBDNXNOJIKML-UHFFFAOYSA-N |
| Smiles | CC1CCC2=NC(N)=C(C(C3=CN=CC=C3)=C2C1)C#N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BRD 6989
References for BRD 6989
References are publications that support the biological activity of the product.
Johannessen et al (2017) Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat.Chem.Biol. 13 1102 PMID: 28805801
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Keywords: BRD 6989, BRD 6989 supplier, BRD6989, IL-10, production, enhancers, CDK8, inhibitors, enhances, inhibits, Cytokines, Transcriptional, CDKs, 6438, Tocris Bioscience
1 Citation for BRD 6989
Citations are publications that use Tocris products. Selected citations for BRD 6989 include:
Stephen P et al (2021) Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress. Nucleic Acids Res PMID: 34329458
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