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BRD 6989

Cat. No. 6438 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Cdk8 inhibitor; enhances IL-10 production
Chemical Name: 2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BRD 6989

Binds and inhibits Cdk8 in complex with cyclin C (IC50 ~ 200 nM). Enhances IL-10 production in activated human and murine macrophages and dendritic cells (EC50 is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Also inhibits CDK19 in complex with cyclin C.

Compound Libraries for BRD 6989

BRD 6989 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BRD 6989

M. Wt 264.33
Formula C16H16N4
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 642008-81-9
PubChem ID 3835861
InChI Key QSYBDNXNOJIKML-UHFFFAOYSA-N
Smiles CC1CCC2=NC(N)=C(C(C3=CN=CC=C3)=C2C1)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BRD 6989

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.29 20

Preparing Stock Solutions for BRD 6989

The following data is based on the product molecular weight 264.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 18.92 mL 94.58 mL 189.16 mL
1 mM 3.78 mL 18.92 mL 37.83 mL
2 mM 1.89 mL 9.46 mL 18.92 mL
10 mM 0.38 mL 1.89 mL 3.78 mL

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References for BRD 6989

References are publications that support the biological activity of the product.

Johannessen et al (2017) Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat.Chem.Biol. 13 1102 PMID: 28805801

If you know of a relevant reference for BRD 6989, please let us know.

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1 Citation for BRD 6989

Citations are publications that use Tocris products. Selected citations for BRD 6989 include:

Stephen P et al (2021) Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress. Nucleic Acids Res PMID: 34329458

Do you know of a great paper that uses BRD 6989 from Tocris? Please let us know.

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