BS 181 dihydrochloride

Cat. No. 5608 Submit a Review Datasheet / COA / SDS

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Description: Selective cdk7 inhibitor

Chemical Name: N⁵-(6-Aminohexyl)-3-(1-methylethyl)-N⁷-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride

Purity: ≥99% (HPLC)

Datasheet

Citations

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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BS 181 dihydrochloride

BS 181 dihydrochloride is a selective cdk7 inhibitor (IC₅₀ = 21 nM). Displays >40-fold selectivity for cdk7 over other cdks. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.

Technical Data for BS 181 dihydrochloride

M. Wt	453.45
Formula	C₂₂H₃₂N₆.2HCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1883548-83-1
PubChem ID	91826108
InChI Key	XYXAMTBYYTXHSO-UHFFFAOYSA-N
Smiles	CC(C)C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BS 181 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	45.34	100
	DMSO	45.34	100

Preparing Stock Solutions for BS 181 dihydrochloride

The following data is based on the product molecular weight 453.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.03 mL	22.05 mL
5 mM	0.44 mL	2.21 mL	4.41 mL
10 mM	0.22 mL	1.1 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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Product Datasheets for BS 181 dihydrochloride

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for BS 181 dihydrochloride

References are publications that support the biological activity of the product.

Ali et al (2009) The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 69 6208 PMID: 19638587

If you know of a relevant reference for BS 181 dihydrochloride, please let us know.

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Citations for BS 181 dihydrochloride

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