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BSJ-Bump

Cat. No. 6922 Submit a Review Datasheet / COA / SDS

Discontinued Product

6922 has been discontinued.

View all Negative Controls products.
Description: Negative control for BSJ-03-123 (Cat. No. 6921)
Chemical Name: N-(2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-2-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Datasheets References

Biological Activity for BSJ-Bump

BSJ-Bump is a negative control for BSJ-03-123 (Cat. No. 6921). Displays binding and no degradation of Cdk6 in vitro.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for BSJ-Bump

M. Wt 951.05
Formula C48H58N10O11
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2409918-48-3
Smiles O=C1N(C2CCCC2)C3=NC(NC4=CC=C(N5CCN(CC5)CCOCCOCCOCCNC(COC6=C(C7=CC=C6)C(N(C7=O)C8C(N(C)C(CC8)=O)=O)=O)=O)C=N4)=NC=C3C(C)=C1C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for BSJ-Bump

References are publications that support the biological activity of the product.

Brand et al (2019) Homolog-selective degradation as a strategy to probe the function of CDK6 in AML. Cell Chem.Biol. 26 300 PMID: 30595531

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Keywords: BSJ-Bump, BSJ-Bump supplier, protac, negative, control, proteolysis, targeting, chimera, cdk6, cyclin, dependent, kinase, 6, degraders, protacs, Negative, Controls, 6922, Tocris Bioscience

Citations for BSJ-Bump

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Currently there are no citations for BSJ-Bump.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia