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Submit ReviewBTT 3033
Description: Selective inhibitor of integrin α2β1
Chemical Name: 1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide
Purity: ≥98% (HPLC)
Biological Activity for BTT 3033
BTT 3033 is a selective inhibitor of integrin α2β1 (EC50 = 130 nM for α2β1 binding to collagen I). Binds to the α2I domain. Exhibits selectivity for α2β1 over integrins α3β1, α4β1, α5β1 and αv. BTT 3033 inhibits platelet aggregation to collagen I coated capillaries under flow and inhibits binding of α2-expressing CHO cells to collagen I under shear stress conditions. Neurogenic and thromboxane A2-induced human prostate smooth muscle contraction are also inhibited by BTT 3033.
Compound Libraries for BTT 3033
BTT 3033 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for BTT 3033
| M. Wt | 465.5 |
| Formula | C23H20FN5O3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1259028-99-3 |
| PubChem ID | 49841251 |
| InChI Key | NSLIQOPYDUKWTA-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(N2N=CC(S(N(C3=CC=C(NC(NC4=CC=CC=C4)=O)C=C3)C)(=O)=O)=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BTT 3033
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.55 | 100 |
Preparing Stock Solutions for BTT 3033
The following data is based on the product molecular weight 465.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.15 mL | 10.74 mL | 21.48 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.3 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.15 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
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Product Datasheets for BTT 3033
References for BTT 3033
References are publications that support the biological activity of the product.
Nissinen et al (2012) Novel a2 beta 1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. J.Cell Biol. 287 44694 PMID: 23132859
Li et al (2021) Phosphoproteomics identifies potential downstream targets of the integrin α2β1 inhibitor BTT-3033 in prostate stromal cells. Ann.Transl.Med. 9 1380 PMID: 34733932
If you know of a relevant reference for BTT 3033, please let us know.
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Keywords: BTT 3033, BTT 3033 supplier, BTT3033, selective, inhibitors, inhibits, integrins, receptors, alpha2beta1, α2β1, a2b1, collagen, 1, cell, adhesion, Integrins, Cell, Adhesion, Molecules, 4724, Tocris Bioscience
4 Citations for BTT 3033
Citations are publications that use Tocris products. Selected citations for BTT 3033 include:
Li et al (2021) Phosphoproteomics identifies potential downstream targets of the integrin α2β1 inhibitor BTT-3033 in prostate stromal cells. Ann.Transl.Med. 9 1380 PMID: 34733932
Elaine T et al (2021) Collagen I Fibrous Substrates Modulate the Proliferation and Secretome of Estrogen Receptor-Positive Breast Tumor Cells in a Hormone-Restricted Microenvironment. ACS Biomater Sci Eng 7 2430-2443 PMID: 33688723
Mogami (2018) Collagen Type 1 accelerates healing of ruptured fetal membranes. Sci Rep 8 696 PMID: 29330408
Gertraud et al (2023) How the mechanobiology orchestrates the iterative and reciprocal ECM-cell cross-talk that drives microtissue growth. Sci Adv 9 eadd9275 PMID: 36989370
Do you know of a great paper that uses BTT 3033 from Tocris? Please let us know.
Reviews for BTT 3033
Average Rating: 3 (Based on 1 Review.)
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Collagen type 1 activated collagen receptor discoidin domain receptor.
By
Anonymous on 02/21/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: 3D Culture Matrix
10 μg/ml treat 24h and 48h
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