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Submit ReviewBYK 49187
Description: PARP-1 and PARP-2 inhibitor
Chemical Name: 4,5-Dihydro-2-[4-(4-methyl-1H-imidazol-4-yl)-1-piperidinyl]-6H-imidazo[4,5,1-ij]quinolin-6-one
Purity: ≥98% (HPLC)
Biological Activity for BYK 49187
BYK 49187 is a PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively). Displays potent inhibitory activity against human PARP-1 in cell-free and cellular assays in vitro; reduces myocardial infarct size in vivo.
Technical Data for BYK 49187
| M. Wt | 335.4 |
| Formula | C19H21N5O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 163120-31-8 |
| PubChem ID | 15285131 |
| InChI Key | YKJJROIKVYSPDH-UHFFFAOYSA-N |
| Smiles | O=C2CCN3C1=C(N=C3N4CCC(C5=C(C)N=CN5)CC4)C=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BYK 49187
References for BYK 49187
References are publications that support the biological activity of the product.
Eltze et al (2008) Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol.Pharmacol. 74 1587 PMID: 18809672
Sunderland et al (2011) 5-Benzamidoisoquinolin-1-ones and 5-(omega-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). J.Med.Chem. 54 2049 PMID: 21417348
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Keywords: BYK 49187, BYK 49187 supplier, BYK49187, poly(adp-ribose), polymerases, inhibitors, inhibits, parp-1, parp-2, Poly(ADP-ribose), Polymerase, 3735, Tocris Bioscience
Citations for BYK 49187
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