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Description: TNF-α inhibitor
Chemical Name: 3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone]
Purity: ≥98% (HPLC)
Biological Activity for C 87
C 87 is a TNF-α inhibitor (Kd = 110 nM for hTNF-α). Inhibits TNF-α-induced cytotoxicity in L929 fibroblast cells. Attenuates inflammation and increases survival in a mouse hepatitis model.
Technical Data for C 87
| M. Wt | 502.93 |
| Formula | C24H15ClN6O3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 332420-90-3 |
| PubChem ID | 5756872 |
| InChI Key | VELQTEBILFDDQX-SLMZUGIISA-N |
| Smiles | O=C1N(C4=NC(C5=CC=CC=C5)=CS4)N=C(C3=CC=CC=C3)/C1=N/NC2=CC([N+]([O-])=O)=C(Cl)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for C 87
References for C 87
References are publications that support the biological activity of the product.
Ma et al (2014) A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. J.Biol.Chem. 289 12457 PMID: 24634219
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Keywords: C 87, C 87 supplier, TNF-alpha, TNF-a, TNF-α, tumor, necrosis, factor, inflammation, inhibitors, C87, 1609281-56-2, inhibits, Cytokines, 5484, Tocris Bioscience
2 Citations for C 87
Citations are publications that use Tocris products. Selected citations for C 87 include:
Minsoo et al (2019) Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation. Cell Rep 28 2923-2938.e8 PMID: 31509752
Markus et al (2019) Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization. J Biol Chem 294 4368-4380 PMID: 30670595
Reviews for C 87
Average Rating: 4.5 (Based on 2 Reviews.)
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Combinatorial treatments.
By
MARINA KOUTSIOUMPA on 10/13/2022
Assay Type: In Vitro
Species: Human
Combinatorial treatments of the TNF-alpha inhibitor with chemotherapeutics led to synergistic apoptotic phenotype in vitro.
Works Well..
By
Purnima Gupta on 01/10/2018
Assay Type: In Vitro
Species: Mouse
Used in Fibroblast cytotoxicity assay
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