C34

Cat. No. 5373 8 Citations Submit a Review Datasheet / COA / SDS

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Description: TLR4 inhibitor

Alternative Names: TLR4-IN-C34

Chemical Name: 1-Methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside 3,4,6-triacetate

Datasheet

Citations (8)

Reviews

Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for C34

C34 is a TLR4 inhibitor; attenuates TLR4 signaling in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis (NEC). Also suppresses LPS signaling in human ileum displaying NEC ex-vivo. Displays no significant effects on signaling via TLR2 or TLR9.

Compound Libraries for C34

C34 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for C34

M. Wt	389.4
Formula	C₁₇H₂₇NO₉
Storage	Store at -20°C
CAS Number	40592-88-9
PubChem ID	91691128
InChI Key	KMIQMFHPUJUDMC-HHARLNAUSA-N
Smiles	CC(OC[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](NC(C)=O)[C@@H](OC(C)C)O1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for C34

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	19.47	50
	DMSO	38.94	100

Preparing Stock Solutions for C34

The following data is based on the product molecular weight 389.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.84 mL	25.68 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.28 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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Product Datasheets for C34

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for C34

References are publications that support the biological activity of the product.

Neal et al (2013) Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One 8 e65779 PMID: 23776545

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Keywords: C34, C34 supplier, TLR4, signaling, mediated, inflammatory, diseases, inhibitors, inhibits, endotoxemia, necrotizing, enterocolitis, NEC, TLR4-IN-C34, Toll-like, Receptors, 5373, Tocris Bioscience

8 Citations for C34

Citations are publications that use Tocris products. Selected citations for C34 include:

Zhang et al (2019) CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes. BMC Immunol 20 7 PMID: 30674283

Zhou et al (2019) Lung cancer cells release high mobility group box 1 and promote the formation of neutrophil extracellular traps. Oncol Lett 18 181 PMID: 31289487

Alessandro et al (2021) Doxorubicin induces an alarmin-like TLR4-dependent autocrine/paracrine action of Nucleophosmin in human cardiac mesenchymal progenitor cells. BMC Biol 19 124 PMID: 34134693

Maurizio C et al (2022) Extracellular Nucleophosmin Is Increased in Psoriasis and Correlates With the Determinants of Cardiovascular Diseases. Front Cardiovasc Med 9 867813 PMID: 35571214

Stephens et al (2019) Mesenteric Lymphatic Alterations Observed During DSS Induced Intestinal Inflammation Are Driven in a TLR4-PAMP/DAMP Discriminative Manner. Front Immunol 10 557 PMID: 30972059

Minsoo et al (2019) Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation. Cell Rep 28 2923-2938.e8 PMID: 31509752

Nara et al (2020) TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model. Sci Rep 10 17451 PMID: 33060735

Sun et al (2017) Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-κB signaling in an IL-6-dependent manner. J Neuroinflammation 14 231 PMID: 29178911

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Pathways for C34

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.

C34