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Description: Cell-permeable calmodulin agonist
Alternative Names: Calcium-like peptide 1
Biological Activity for CALP1
CALP1 is a cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM). Shown to protect pancreatic acinar cells from gossypol (Cat.No. 1964) induced necrosis. Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo.
Technical Data for CALP1
| M. Wt | 842.09 |
| Formula | C40H75N9O10 |
| Sequence | VAITVLVK |
| Storage | Desiccate at -20°C |
| CAS Number | 145224-99-3 |
| PubChem ID | 10440555 |
| InChI Key | HTOHLCKNMRKYLK-KVZSNLRASA-N |
| Smiles | [H]N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CALP1
References for CALP1
References are publications that support the biological activity of the product.
Manion et al (2000) A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis. FASEB J. 14 1297 PMID: 10877822
Houtman et al (2001) Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J.Immunol. 166 861 PMID: 11145661
Ten Broeke et al (2003) Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma. Eur.J.Pharmacol. 476 151 PMID: 12969760
Villain et al (2000) De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem. 274 2676
Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8 PMID: 28252652
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Keywords: CALP1, CALP1 supplier, Cell-permeable, calmodulin, agonists, inhibitors, inhibits, Ca2+-sensitive, ion, channels, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, Calcium-like, peptide1, peptide, 1, Other, Channel, Modulators, 2090, Tocris Bioscience
2 Citations for CALP1
Citations are publications that use Tocris products. Selected citations for CALP1 include:
Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8 PMID: 28252652
Tzeng et al (2012) The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice. Cardiovasc Res 96 533 PMID: 22886848
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