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Submit ReviewCCG 1423
Description: Rho/SRF pathway inhibitor; induces intermediate mesoderm differentiation from ESCs
Chemical Name: N-[2-[(4-Chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)benzamide
Purity: ≥99% (HPLC)
Biological Activity for CCG 1423
CCG 1423 is a Rho/SRF pathway inhibitor; stimulates apoptosis of a melanoma cell line overexpressing RhoC (A375M2). Suppresses Rho-dependent invasion of PC-3 prostate cancer cells in vitro and inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells. When used in combination with Retinoic acid, LY 294002 and Pyridone 6, it induces intermediate mesoderm differentiation from ESCs.
Compound Libraries for CCG 1423
CCG 1423 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for CCG 1423
| M. Wt | 454.75 |
| Formula | C18H13ClF6N2O3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 285986-88-1 |
| PubChem ID | 2726015 |
| InChI Key | DSMXVSGJIDFLKP-UHFFFAOYSA-N |
| Smiles | O=C(NOC(C)C(NC2=CC=C(Cl)C=C2)=O)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CCG 1423
References for CCG 1423
References are publications that support the biological activity of the product.
Mae et al (2010) Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. Biochem.Biophys.Res.Commun. 393 877 PMID: 20171952
Evelyn et al (2007) CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Mol.Cancer Ther. 6 2249 PMID: 17699722
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Keywords: CCG 1423, CCG 1423 supplier, CCG1423, Rho, SRF, pathway, inhibitors, inhibits, intermediate, mesoderm, differentiation, ESC, embryonic, stem, cells, serum, response, factors, cancer, ESCs, and, iPSC, 5233, Tocris Bioscience
4 Citations for CCG 1423
Citations are publications that use Tocris products. Selected citations for CCG 1423 include:
Aarthi et al (2021) Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3. Viruses 13 PMID: 34452398
Li et al (2021) Regulation of the Muscarinic M3 Receptor by Myocardin-Related Transcription Factors. Front Physiol 12 710968 PMID: 34539433
Li et al (2021) Cell Type Dependent Suppression of Inflammatory Mediators by Myocardin Related Transcription Factors. Front Physiol 12 732564 PMID: 34671275
Preet M et al (2020) Narciclasine, an isocarbostyril alkaloid, has preferential activity against primary effusion lymphoma. Sci Rep 10 5712 PMID: 32235878
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