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Submit ReviewCCT 031374 hydrobromide
Discontinued Product
4675 has been discontinued.
Description: Inhibits TCF-dependent transcription; lowers β-catenin levels
Chemical Name: 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone hydrobromide
Purity: ≥98% (HPLC)
Biological Activity for CCT 031374 hydrobromide
CCT 031374 hydrobromide is an inhibitor of TCF-dependent transcription. Blocks BIO-induced β-catenin stabilization; reduces nuclear and cytosolic β-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.
Technical Data for CCT 031374 hydrobromide
| M. Wt | 434.33 |
| Formula | C23H19N3O.HBr |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1219184-91-4 |
| PubChem ID | 18554738 |
| InChI Key | MPILENOYNNNGKO-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC=C(C5=CC=CC=C5)C=C4)CN1C3=C(C=CC=C3)N2C1=NCC2.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CCT 031374 hydrobromide
References for CCT 031374 hydrobromide
References are publications that support the biological activity of the product.
Ewan et al (2010) A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 70 5963 PMID: 20610623
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Keywords: CCT 031374 hydrobromide, CCT 031374 hydrobromide supplier, CCT031374, hydrobromide, TCF, transcription, inhibitors, inhibits, beta-catenin, b-catenin, β-catenin, stabilization, Beta-catenin, 4675, Tocris Bioscience
2 Citations for CCT 031374 hydrobromide
Citations are publications that use Tocris products. Selected citations for CCT 031374 hydrobromide include:
Brown et al (2019) Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells. Aging Cell 18 e12844 PMID: 30548452
Liu et al (2015) β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression. Nature 36 1572 PMID: 26496941
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