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Submit ReviewCDP 840 hydrochloride
Description: Potent and selective PDE4 inhibitor
Chemical Name: 4-[(2R)-2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-pyridine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for CDP 840 hydrochloride
CDP 840 hydrochloride is a potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 12 nM for native PDE4). Competitively inhibits all PDE4 isoenzymes (IC50 values are 4, 9, 9 and 45 nM for PDE4A, PDE4B, PDE4C and PDE4D human recombinant isoforms expressed in yeast).
Technical Data for CDP 840 hydrochloride
| M. Wt | 409.95 |
| Formula | C25H27NO2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| PubChem ID | 89809670 |
| InChI Key | DQXFOLCDYKWSIT-GNAFDRTKSA-N |
| Smiles | COC1=C(OC2CCCC2)C=C([C@@H]([C@]4=CC=CC=C4)CC3=CC=NC=C3)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CDP 840 hydrochloride
References for CDP 840 hydrochloride
References are publications that support the biological activity of the product.
Hughes et al (1996) The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. Br.J.Pharmacol. 118 1183 PMID: 8818342
Perry et al (1998) CDP840: a novel inhibitor of PDE-4. Cell Biochem.Biophys. 29 113 PMID: 9631241
Cooper et al (1999) A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo. Br.J.Pharmacol. 126 1863 PMID: 10372831
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Keywords: CDP 840 hydrochloride, CDP 840 hydrochloride supplier, CDP840, hydrochloride, phosphodiesterases, pde4, isoenzymes, inhibitors, inhibits, potent, selective, 162542-90-7, Phosphodiesterases, 3936, Tocris Bioscience
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