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Cediranib

Cat. No. 7454 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent inhibitor of VEGFR, PDGFR and FGFR
Chemical Name: 4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Cediranib

Cediranib is a highly potent and ATP-competitive inhibitor of VEGFR2 (IC50 = <1 nM). Cediranib also potently inhibits PDGFR1, VEGFR3, VEGFR1, c-Kit, PDGFR2 and FGFR1 (IC50 values are 2, 3, 5, 5, 26 and 36 nM, respectively), and inhibits CSF-1R, Src, and Abl (IC50 values are 110, 130 and 260 nM, respectively). Cediranib induces hypoxia, prevents VEGF-induced angiogenesis and suppresses homology-directed DNA repair (HDR) factors BRCA1/2 and RAD51. Cediranib decreases cell motility, proliferation and cell viability. Cediranib is active in vivo.

Compound Libraries for Cediranib

Cediranib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Cediranib

M. Wt 450.51
Formula C25H27FN4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 288383-20-0
PubChem ID 9933475
InChI Key XXJWYDDUDKYVKI-UHFFFAOYSA-N
Smiles FC1=C(OC2=NC=NC=3C=C(OCCCN4CCCC4)C(OC)=CC23)C=CC=5NC(=CC15)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cediranib

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.05 100
ethanol 45.05 100

Preparing Stock Solutions for Cediranib

The following data is based on the product molecular weight 450.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.1 mL 22.2 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References for Cediranib

References are publications that support the biological activity of the product.

Wedge et al (2005) AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res. 65 4389 PMID: 15899831

Kaplan et al (2019) Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51. Sci.Transl.Med. 11 PMID: 31092693

Momeny et al (2020) Cediranib, an inhibitor of vascular endothelial growth factor receptor kinases, inhibits proliferation and invasion of prostate adenocarcinoma cells Eur.J.Pharmacol. 882 PMID: 32593665

If you know of a relevant reference for Cediranib, please let us know.

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Citations for Cediranib

Citations are publications that use Tocris products.

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Reviews for Cediranib

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for Cediranib

VEGF Signaling Pathway

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.