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Submit ReviewCeftriaxone disodium salt
Description: Neuroprotective; increases EAAT2 expression and activity
Chemical Name: 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt
Purity: ≥98% (HPLC)
Biological Activity for Ceftriaxone disodium salt
β-lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.
Technical Data for Ceftriaxone disodium salt
| M. Wt | 598.54 |
| Formula | C18H16N8Na2O7S3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 104376-79-6 |
| PubChem ID | 9601224 |
| InChI Key | FDRNWTJTHBSPMW-ZJTMPOFJSA-L |
| Smiles | [Na+].[Na+].CO\N=C(/C(=O)NC1C(=O)N2C(C([O-])=O)=C(CSC3=NC(=O)C([O-])=NN3C)CS[C@]12[H])C1=CSC(N)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ceftriaxone disodium salt
References for Ceftriaxone disodium salt
References are publications that support the biological activity of the product.
Rothstein et al (2005) β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433 73 PMID: 15635412
Rawls et al (2007) The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats. Br.J.Pharmacol. 151 1095 PMID: 17592517
Lipski et al (2007) Neuroprotective potential of ceftri. in in vitro models of stroke. Neuroscience 146 617 PMID: 17363173
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Keywords: Ceftriaxone disodium salt, Ceftriaxone disodium salt supplier, GLT-1, EAAT2, glutamate, transporters, activators, expression, Excitatory, Amino, Acid, Transporters, Monoamine, Neurotransmitter, antibiotics, Glutamate, Antibiotics, 3732, Tocris Bioscience
Citations for Ceftriaxone disodium salt
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Currently there are no citations for Ceftriaxone disodium salt.
Reviews for Ceftriaxone disodium salt
Average Rating: 5 (Based on 1 Review.)
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Increase GLT1 expression.
By
Anonymous on 01/25/2018
Species: Human
Used it to increase protein expression of GLT1 in mouse brain. It worked very well and easily dissolves in saline.
Literature in this Area
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Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.