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Submit ReviewCelecoxib
Description: Selective cyclooxygenase-2 (COX-2) inhibitor
Alternative Names: SC 58635,Celebrex
Chemical Name: 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
Purity: ≥99% (HPLC)
Biological Activity for Celecoxib
Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). Celecoxib is an anti-inflammatory with shorter plasma half-life in vivo than SC 58121. Displays chemopreventive activity in in vivo tumor models.
Compound Libraries for Celecoxib
Celecoxib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for Celecoxib
| M. Wt | 381.37 |
| Formula | C17H14F3N3O2S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 169590-42-5 |
| PubChem ID | 2662 |
| InChI Key | RZEKVGVHFLEQIL-UHFFFAOYSA-N |
| Smiles | CC(C=C3)=CC=C3C1=CC(C(F)(F)F)=NN1C2=CC=C(S(=O)(N)=O)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Celecoxib
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.53 | 25 | |
| ethanol | 19.07 | 50 |
Preparing Stock Solutions for Celecoxib
The following data is based on the product molecular weight 381.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.24 mL | 26.22 mL | 52.44 mL |
| 2.5 mM | 1.05 mL | 5.24 mL | 10.49 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.24 mL |
| 25 mM | 0.1 mL | 0.52 mL | 1.05 mL |
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Product Datasheets for Celecoxib
References for Celecoxib
References are publications that support the biological activity of the product.
Penning et al (1997) Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J.Med.Chem. 40 1347 PMID: 9135032
DeWitt (1999) Cox-2-selective Inhibitors: the new super aspirins. Mol.Pharmacol. 55 625 PMID: 10101019
Harris et al (2000) Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor. Cancer Res. 60 2101 PMID: 10786667
If you know of a relevant reference for Celecoxib, please let us know.
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Keywords: Celecoxib, Celecoxib supplier, Selective, cyclooxygenase-2, COX-2, inhibitors, inhibits, Oxygenases, Oxidases, SC58635, prostaglandins, SC, 58635, Celebrex, Cyclooxygenase, 3786, Tocris Bioscience
4 Citations for Celecoxib
Citations are publications that use Tocris products. Selected citations for Celecoxib include:
Christopher J et al (2022) Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res 82 3375-3393 PMID: 35819261
Cesare et al (2020) Celecoxib Exerts Neuroprotective Effects in β-Amyloid-Treated SH-SY5Y Cells Through the Regulation of Heme Oxygenase-1: Novel Insights for an Old Drug. Front Cell Dev Biol 8 561179 PMID: 33134292
Bowler et al (2019) CXB Is Associated With Dystrophic Calcification and Aortic Valve Stenosis. JACC Basic Transl Sci 4 135 PMID: 31061914
Oguh-Olayinka et al (2019) The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma. Pathol Oncol Res PMID: 30941737
Do you know of a great paper that uses Celecoxib from Tocris? Please let us know.
Reviews for Celecoxib
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Literature in this Area
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