Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewCetrorelix Acetate
Description: Potent GnRH receptor antagonist
Biological Activity for Cetrorelix Acetate
Cetrorelix Acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist (KD = 0.202 nM, IC50 = 1.21 nM). Suppresses production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which inhibits ovulation. Exhibits antiproliferative effects and displays efficacy against hormone-sensitive cancers in vivo. Also exhibits anxiolytic and antidepressant activity in vivo.
Technical Data for Cetrorelix Acetate
| M. Wt | 1491.11 |
| Formula | C70H92ClN17O14.C2H4O2 |
| Sequence |
XFASYXLRPA (Modifications: X-1 = D-2-Nal and N-terminal Ac, Phe-2 = D-(4-Cl-Phe), Ala-3 = D-(3-Pyridyl-Ala), X-6 = D-Cit, Ala-10 = D-Ala and C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 145672-81-7 |
| PubChem ID | 25078429 |
| InChI Key | KFEFLCOCAHJBEA-ANRVCLKPSA-N |
| Smiles | CC(O)=O.CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC1=CN=CC=C1)NC(=O)[C@@H](CC1=CC=C(Cl)C=C1)NC(=O)[C@@H](CC1=CC2=C(C=CC=C2)C=C1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cetrorelix Acetate
| Solubility | Soluble in water |
Product Datasheets for Cetrorelix Acetate
References for Cetrorelix Acetate
References are publications that support the biological activity of the product.
Beckers et al (1997) Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal.Biochem. 251 17 PMID: 9300077
Grundker and Emons (2003) Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod.Biol.Endocrinol. 1 65 PMID: 14594454
Telegdy et al (2009) Effects of the LHRH antagonist cetro. on the brain function in mice. Neuropeptides 43 229 PMID: 19375162
If you know of a relevant reference for Cetrorelix Acetate, please let us know.
View Related Products by Target
View Related Products by Product Action
View all Gonadotropin-Releasing Hormone Receptor Antagonists
Keywords: Cetrorelix Acetate, Cetrorelix Acetate supplier, Potent, GnRH, antagonists, Peptide, Receptors, Gonadotropin-releasing, Hormone, gonadotrophin, Gonadotrophin-Releasing, 3536, Tocris Bioscience
Citations for Cetrorelix Acetate
Citations are publications that use Tocris products.
Currently there are no citations for Cetrorelix Acetate. Do you know of a great paper that uses Cetrorelix Acetate from Tocris? Please let us know.
Reviews for Cetrorelix Acetate
There are currently no reviews for this product. Be the first to review Cetrorelix Acetate and earn rewards!
Have you used Cetrorelix Acetate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image