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Submit ReviewCGP 52411
Description: EGFR inhibitor. Also inhibits Aβ42 fibril formation
Alternative Names: DAPH
Chemical Name: 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione
Purity: ≥99% (HPLC)
Biological Activity for CGP 52411
CGP 52411 is a selective inhibitor of the epidermal growth factor receptor (EGFR) (IC50 = 0.3 μM in vitro). Also inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease. Eliminates calcium influx potential when coincubated with amyloid β-peptide (1-42) (Cat.No. 1428); reduces neurotoxicity by blocking Ca2+ influx into neuronal cells.
Technical Data for CGP 52411
| M. Wt | 329.35 |
| Formula | C20H15N3O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 145915-58-8 |
| PubChem ID | 1697 |
| InChI Key | AAALVYBICLMAMA-UHFFFAOYSA-N |
| Smiles | O=C2NC(C1=CC(NC4=CC=CC=C4)=C(NC3=CC=CC=C3)C=C12)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CGP 52411
References for CGP 52411
References are publications that support the biological activity of the product.
Buchdunger et al (1994) 4,5-dianilinophthalimide: a protein tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity. Proc.Natl.Acad.Sci. 91 2334 PMID: 8134396
Blanchard et al (2004) Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule. Proc.Natl.Acad.Sci. 101 14326 PMID: 15388848
Wang et al (2008) Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci. 105 7159 PMID: 18480256
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Citations for CGP 52411
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Currently there are no citations for CGP 52411.
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