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Submit ReviewChaetoglobosin A
Description: Antibiotic; selectively induces apoptosis of CLL cells
Chemical Name: (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-4,7,14,14a,15,15a,16a,16b-Octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-3H-cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione
Purity: ≥98% (HPLC)
Biological Activity for Chaetoglobosin A
Chaetoglobosin A is an antibiotic; preferentially induces apoptosis in chronic lymphocytic leukemia (CLL) cells over normal B cells. Inhibits actin polymerization and leads to the accumulation of cells in G2 phase.
Technical Data for Chaetoglobosin A
| M. Wt | 528.64 |
| Formula | C32H36N2O5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 50335-03-0 |
| PubChem ID | 102601376 |
| InChI Key | OUMWCYMRLMEZJH-VOXRAUTJSA-N |
| Smiles | O=C1[C@]23[C@]([H])([C@H](CC4=CNC5=CC=CC=C45)N1)[C@H](C)[C@]6(C)[C@]([H])([C@@]2(/C=C/C[C@H](C)/C=C(C)/[C@@H](O)C(/C=C/C3=O)=O)[H])O6 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Chaetoglobosin A
References for Chaetoglobosin A
References are publications that support the biological activity of the product.
Knudsen et al (2014) Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia 28 1289 PMID: 24280868
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Keywords: Chaetoglobosin A, Chaetoglobosin A supplier, Antibiotics, induces, apoptosis, inducer, selective, chronic, lymphocytic, leukemia, CLL, actin, polymerisation, inhibitor, inhbits, Apoptosis, Inducers, Actin, 5804, Tocris Bioscience
Citations for Chaetoglobosin A
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Currently there are no citations for Chaetoglobosin A.
Reviews for Chaetoglobosin A
Average Rating: 5 (Based on 1 Review.)
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Apoptotic properties of Chaetoglobosin A was assessed.
By
Anonymous on 01/24/2019
Assay Type: In Vitro
Species: Human
Apoptotic properties of Chaetoglobosin A was assessed. Apoptosis triggered by Chaetoglobosin A and DR5 MAb was measured simultaneously.
