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CHS 828

Cat. No. 6753 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: NAMPT inhibitor; active in vivo and cytotoxic
Chemical Name: N-[6-(4-Chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinylguanidine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CHS 828

CHS 828 is a NAMPT inhibitor. Decreases cellular level of NAD+. Selectively increases intracellular ROS levels in cancer cells but not normal cells. Active in vivo and cytotoxic.

Compound Libraries for CHS 828

CHS 828 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CHS 828

M. Wt 371.86
Formula C19H22ClN5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 200484-11-3
PubChem ID 148198
InChI Key BOIPLTNGIAPDBY-UHFFFAOYSA-N
Smiles ClC1=CC=C(C=C1)OCCCCCCN/C(NC#N)=N/C2=CC=NC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CHS 828

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.19 100

Preparing Stock Solutions for CHS 828

The following data is based on the product molecular weight 371.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.45 mL 26.89 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.34 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets for CHS 828

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for CHS 828

References are publications that support the biological activity of the product.

Hjarnaa et al (1999) CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo. Cancer Res. 59 5751 PMID: 10582695

Karpov et al (2018) Nicotinamide phosphoribosyltransferase inhibitor as a novel payload for antibody-drug conjugates. ACS Med.Chem.Lett. 9 838 PMID: 30128077

Olesen et al (2008) Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem.Biophys.Res.Commun. 367 799 PMID: 18201551

If you know of a relevant reference for CHS 828, please let us know.

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Keywords: CHS 828, CHS 828 supplier, CHS828, NAMPT, inhibitors, inhibits, ROS, cytotoxic, active, in, vivo, 6753, Tocris Bioscience

1 Citation for CHS 828

Citations are publications that use Tocris products. Selected citations for CHS 828 include:

Rui et al (2021) Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets. J Clin Invest 131 PMID: 34128839

Do you know of a great paper that uses CHS 828 from Tocris? Please let us know.

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Literature in this Area

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Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.