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Submit ReviewCID 2745687
Description: GPR35 antagonist
Chemical Name: 1-(2,4-Difluorophenyl)-5-[[2-[[(1,1-dimethylehyl)amino]thioxomethyl]hydrazinylidene]methyl]-1H-pyrazole-4-carboxylic acid methyl ester
Purity: ≥98% (HPLC)
Biological Activity for CID 2745687
CID 2745687 is a competitive, reversible antagonist of the orphan receptor GPR35 (Ki = 12.8 nM). Blocks the GPR35-mediated increase in ERK1/2 phosphorylation and β-arrestin recruitment induced by pamoic acid.
Compound Libraries for CID 2745687
CID 2745687 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CID 2745687
| M. Wt | 395.43 |
| Formula | C17H19F2N5O2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 264233-05-8 |
| PubChem ID | 9581011 |
| InChI Key | CYNLZIBKERMMOA-AWQFTUOYSA-N |
| Smiles | FC1=CC(F)=CC=C1N2C(/C=N/NC(NC(C)(C)C)=S)=C(C(OC)=O)C=N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CID 2745687
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.54 | 100 | |
| ethanol | 3.95 | 10 |
Preparing Stock Solutions for CID 2745687
The following data is based on the product molecular weight 395.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.64 mL | 25.29 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.06 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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Product Datasheets for CID 2745687
References for CID 2745687
References are publications that support the biological activity of the product.
Zhao et al (2010) Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol.Pharmacol. 78 560 PMID: 20826425
Jenkins et al (2012) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 343 683 PMID: 22967846
If you know of a relevant reference for CID 2745687, please let us know.
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Keywords: CID 2745687, CID 2745687 supplier, CID2745687, orphan, receptors, antagonists, GPR35, antagonist, 4293, Tocris Bioscience
1 Citation for CID 2745687
Citations are publications that use Tocris products. Selected citations for CID 2745687 include:
Sun et al (2014) Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci Rep 4 4934 PMID: 24816792
Do you know of a great paper that uses CID 2745687 from Tocris? Please let us know.
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