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CIMBA hydrochloride

Cat. No. 7812 Submit a Review Datasheet / COA / SDS
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Description: Potent and selective G protein-coupled estrogen receptor (GPER) antagonist
Chemical Name: N-[2-Cyclohexyl-4-(1-methylethyl)phenyl]-4-methoxybenzenemethanamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
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Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CIMBA hydrochloride

CIMBA hydrochloride is a potent G protein-coupled estrogen receptor (GPER) antagonist (IC50 = 75 nM). In vivo, it prevents the formation of estrogen-induced cholesterol gallstones by inhibiting the GPER pathway in female ovariectomized mice.

Licensing Information

Sold under licence from Saint Louis University.

Technical Data for CIMBA hydrochloride

M. Wt 373.97
Formula C23H31NO.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key KWVXXQOTMDKOID-UHFFFAOYSA-N
Smiles CC(C)C(C=C1C2CCCCC2)=CC=C1NCC(C=C3)=CC=C3OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CIMBA hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.4 100
ethanol 37.4 100

Preparing Stock Solutions for CIMBA hydrochloride

The following data is based on the product molecular weight 373.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.37 mL 26.74 mL
5 mM 0.53 mL 2.67 mL 5.35 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets for CIMBA hydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for CIMBA hydrochloride

References are publications that support the biological activity of the product.

DeLeon et al (2020) A novel GPER antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice. J.Lipid Res. 61 767 PMID: 32127396

If you know of a relevant reference for CIMBA hydrochloride, please let us know.

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Citations for CIMBA hydrochloride

Citations are publications that use Tocris products.

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Pathways for CIMBA hydrochloride

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.