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Submit ReviewCisapride
Description: 5-HT4 agonist; stimulates intestinal ACh release
Alternative Names: R 51619
Chemical Name: (±)-4-Amino-5-chloro-N-[1-[(3R*,4S*)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide
Purity: ≥99% (HPLC)
Biological Activity for Cisapride
Cisapride is a 5-HT4 receptor agonist and gastrokinetic agent. Stimulates intestinal acetylcholine release, possibly via 5-HT4 receptor-dependent and -independent mechanisms, leading to increased intestinal motility.
Compound Libraries for Cisapride
Cisapride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Cisapride
| M. Wt | 465.95 |
| Formula | C23H29ClFN3O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 81098-60-4 |
| PubChem ID | 6917698 |
| InChI Key | VTMCXFGKGQNNBD-IWONEHLMSA-N |
| Smiles | CO[C@H]1CN(CCCOC2=CC=C(F)C=C2)CC[C@H]1NC(=O)C1=C(OC)C=C(N)C(Cl)=C1.CO[C@@H]1CN(CCCOC2=CC=C(F)C=C2)CC[C@@H]1NC(=O)C1=C(OC)C=C(N)C(Cl)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cisapride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.59 | 100 |
Preparing Stock Solutions for Cisapride
The following data is based on the product molecular weight 465.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.15 mL | 10.73 mL | 21.46 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.29 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.15 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
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Product Datasheets for Cisapride
References for Cisapride
References are publications that support the biological activity of the product.
Briejer et al (1993) Cisapride and a structural analogue, R 76,186, are 5-hydroxytryptamine4 (5-HT4) receptor agonists on the guinea-pig colon ascendens. Naunyn Schmiedebergs Arch.Pharmacol. 347 464 PMID: 8321323
Schuurkes et al (1985) Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig. J.Pharmacol.Exp.Ther. 234 775 PMID: 3897516
Taniyama et al (1991) Cisapride stimulates motility of the intestine via the 5-hydroxytryptamine receptors. J.Pharmacol.Exp.Ther. 258 1098 PMID: 1890614
If you know of a relevant reference for Cisapride, please let us know.
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Keywords: Cisapride, Cisapride supplier, 5-HT4, agonists, stimulates, Serotonin, Receptors, 5-Hydroxytryptamine, stimulate, ACh, acetylcholine, release, nicotinic, muscarinic, nAChR, R51619, R, 51619, Other, Acetylcholine, Non-selective, Muscarinics, 1695, Tocris Bioscience
4 Citations for Cisapride
Citations are publications that use Tocris products. Selected citations for Cisapride include:
Padayatti et al (2013) A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4). Mol Cell Proteomics 12 1259 PMID: 23378516
Beattie et al (2011) The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties. Front Pharmacol 2 25 PMID: 21687517
Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728
Xiang et al (2005) Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes. J Neurophysiol 93 1145 PMID: 15738272
Do you know of a great paper that uses Cisapride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.